Projects per year
Personal profile
Research interests
Dr. Yasin Uzun uses bioinformatics and genomics methods to understand gene regulation at the molecular level. For this purpose, he employs Systems Biology approaches to utilize next generation sequencing data, with a particular emphasis on single-cell genomics for modeling epigenetic control. His studies in this field reveal the molecular mechanisms that switch the genes on and off during cell differentiation. In this way, he investigates how the dysregulation in these control mechanisms are associated with various genetic diseases with a particular focus on cancer and how this information can present novel therapeutic opportunities.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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Integrated frameworks for single-cell epigenomics based transcriptional regulatory networks
Uzun, Y. (PI)
National Institute of General Medical Sciences
9/1/23 → 7/31/25
Project: Research project
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Advances in computational and experimental approaches for deciphering transcriptional regulatory networks: Understanding the roles of cis-regulatory elements is essential, and recent research utilizing MPRAs, STARR-seq, CRISPR-Cas9, and machine learning has yielded valuable insights
Moeckel, C., Mouratidis, I., Chantzi, N., Uzun, Y. & Georgakopoulos-Soares, I., Jul 2024, In: BioEssays. 46, 7, 2300210.Research output: Contribution to journal › Review article › peer-review
Open Access -
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis
Hattori, T., Fundora, K. A., Hamamoto, K., Opozda, D. M., Liang, X., Liu, X., Zhang, J., Uzun, Y., Takahashi, Y. & Wang, H. G., 2024, In: Autophagy. 20, 2, p. 349-364 16 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Integrating Single-Cell Methylome and Transcriptome Data with MAPLE
Uzun, Y., Wu, H. & Tan, K., 2023, Methods in Molecular Biology. Humana Press Inc., p. 43-54 12 p. (Methods in Molecular Biology; vol. 2624).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions
Morral, C., Ghinnagow, R., Karakasheva, T., Zhou, Y., Thadi, A., Li, N., Yoshor, B., Soto, G. E., Chen, C. H., Aleynick, D., Weinbrom, S., Fulton, M. K., Uzun, Y., Bewtra, M., Kelsen, J. R., Lengner, C. J., Tan, K., Minn, A. J. & Hamilton, K. E., 2023, In: Bio-protocol. 13, 18, e4825.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis
Yang, Y., Mumau, M., Tober, J., Zhu, Q., Bennett, L., Hong, C., Sung, D., Keller, T., Uzun, Y., Gao, P., Shewale, S., Chen, M., Yang, J., Chen, X., Thomas, S. A., Tan, K., Speck, N. A. & Kahn, M. L., May 12 2022, In: Blood. 139, 19, p. 2942-2957 16 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations