Projects per year
Personal profile
Research interests
The main interest of Dr. Yongsoo Kim’s lab is to understand structural and functional organization of the mammalian brain using mice as an animal model. Particularly, Dr. Kim is interested in understanding the neural circuit basis of social behavior and its dysfunction in brain disorders. Social behavior is complex, requiring the integration of multiple sensory modalities, internal state information and memories of prior experience in order to generate highly nuanced responses to diverse environmental scenarios. Impairment of social behavior occurs often in many neurodevelopmental and psychiatric disorders.
Thus, the Kim lab’s goal is to understand how local and brain-wide neural network operate to generate normal social behavior and how such processes are altered in pathological conditions. Toward that goal, Dr. Kim’s lab uses an automated 3D microscopy system called serial two-photon tomography to image whole mouse brains with cellular resolution. Dr. Kim used this imaging method with sophisticated data processing pipeline to systematically analyze target signals in the entire mouse brain. Previously, he used this method to perform cFos-based neural activity mapping, quantitative cell type mapping and brain-wide axonal projection mapping.
Currently, Dr. Kim’s lab is developing three-dimensional digital mouse brain atlases across different ages to establish a bioinformatics solution to register detected signals. Using the digital map, he is working on mapping oxytocin and oxytocin receptor-expressing neurons that play an essential role in generating and regulating social behavior. Moreover, he is also working on generating a detailed three-dimensional structure of microvaculature in the whole mouse brain.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Training, Cold Spring Harbor Laboratory
2010 → 2015
Visiting Student, University of Oxford
2008 → 2010
PhD, Northwestern University
2004 → 2010
BS, Seoul National University
1996 → 2000
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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Establishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse Brains
Kim, Y. (PI), Gee, J. C. (CoPI) & Ng, L.L.-M. (CoPI)
National Institute of Mental Health
9/15/20 → 9/14/23
Project: Research project
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Understanding cellular architecture of the neurovascular unit and its function in the whole mouse brain
Kim, Y. (PI)
National Institute of Neurological Disorders and Stroke
9/1/18 → 5/31/23
Project: Research project
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Brain-wide input and output wiring diagram of oxytocin neurons and its function in claustrum-endopiriform complex
Kim, Y. (PI)
National Institute of Mental Health
6/1/18 → 2/28/22
Project: Research project
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Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain
Silberfeld, A., Roe, J. M., Ellegood, J., Lerch, J. P., Qiu, L., Kim, Y., Lee, J. G., Hopkins, W. D., Grandjean, J., Ou, Y. & Pourquié, O., Feb 15 2025, In: NeuroImage. 307, 121017.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
Bennett, H. C., Zhang, Q., Wu, Y. T., Manjila, S. B., Chon, U., Shin, D., Vanselow, D. J., Pi, H. J., Drew, P. J. & Kim, Y., Dec 2024, In: Nature communications. 15, 1, 6398.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Brain development
Molnár, Z., Kim, Y., Kronman, F. N., Mueller, M. H. & Price, D. J., Jan 1 2024, Kaufman's Atlas of Mouse Development Supplement: With Coronal Sections. Elsevier, p. 371-390 20 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Cross-modality mapping using image varifolds to align tissue-scale atlases to molecular-scale measures with application to 2D brain sections
Stouffer, K. M., Trouvé, A., Younes, L., Kunst, M., Ng, L., Zeng, H., Anant, M., Fan, J., Kim, Y., Chen, X., Rue, M. & Miller, M. I., Dec 2024, In: Nature communications. 15, 1, 3530.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Developmental mouse brain common coordinate framework
Kronman, F. N., Liwang, J. K., Betty, R., Vanselow, D. J., Wu, Y. T., Tustison, N. J., Bhandiwad, A., Manjila, S. B., Minteer, J. A., Shin, D., Lee, C. H., Patil, R., Duda, J. T., Xue, J., Lin, Y., Cheng, K. C., Puelles, L., Gee, J. C., Zhang, J. & Ng, L. & 1 others, , Dec 2024, In: Nature communications. 15, 1, 9072.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Prizes
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Biobehavioral Research Awards for Innovative New Scientists
Kim, Y. (Recipient), 2018
Prize: Honorary award
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Junior Faculty Research Scholar Award
Kim, Y. (Recipient), Karunanayaka, P. (Recipient) & Howrylak, J. A. (Recipient), 2017
Prize: Honorary award
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