Projects per year
Personal profile
Research interests
During mammalian development, hundreds of cell types derived from a single zygote are maintained throughout cell cycles. Deregulation of cell identity is often associated with pathogenesis such as cancer. Despite identical genetic information, cells with distinct identity are controlled by the differential epigenetic landscape. Dr. Zhonghua Gao's research interest is to understand how cell identity is established and maintained via epigenetic mechanisms, particularly how Polycomb group complexes are involved in regulating chromatin structure and gene transcription.
Dr. Gao's lab has established an in vitro neuronal differentiation model using both mouse and human embryonic stem cells. These efforts led to an identification and characterization of novel essential component for a sub-type of PRC1 complex.
The lab is currently continuing to investigate how this regulation controls cell fate determination as well as its involvement in diseases such as cancer and autism.
Dr. Gao is part of the Stem Cell and Regenerative Biology program at Penn State College of Medicine.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Epigenetic regulation of cell identity by PRC1 complexes
Gao, Z. (PI)
National Institute of General Medical Sciences
8/1/19 → 7/31/22
Project: Research project
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Regulation of ES Cell Cardiac Differentiation by PRC1 Complexes
Gao, Z. (PI)
1/1/17 → 12/31/19
Project: Research project
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AUTS2 disruption causes neuronal differentiation defects in human cerebral organoids through hyperactivation of the WNT/β-catenin pathway
Geng, Z., Tai, Y. T., Wang, Q. & Gao, Z., Dec 2024, In: Scientific reports. 14, 1, 19522.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes
Cai, W., Liu, X., Barajas, S., Xiao, S., Vemula, S., Chen, H., Yang, Y., Bochers, C., Henley, D., Liu, S., Jia, Y., Hong, M., Mays, T. M., Capitano, M. L., Liu, H., Ji, P., Gao, Z., Pasini, D., Wan, J. & Yue, F. & 4 others, , 2024, (Accepted/In press) In: Leukemia.Research output: Contribution to journal › Article › peer-review
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AUTS2 Controls Neuronal Lineage Choice Through a Novel PRC1-Independent Complex and BMP Inhibition
Geng, Z., Wang, Q., Miao, W., Wolf, T., Chavez, J., Giddings, E., Hobbs, R., DeGraff, D. J., Wang, Y., Stafford, J. & Gao, Z., Feb 2023, In: Stem Cell Reviews and Reports. 19, 2, p. 531-549 19 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Bmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells
Yu, H., Gao, R., Chen, S., Liu, X., Wang, Q., Cai, W., Vemula, S., Fahey, A. C., Henley, D., Kobayashi, M., Liu, S. Z., Qian, Z., Kapur, R., Broxmeyer, H. E., Gao, Z., Xi, R. & Liu, Y., Dec 2021, In: Stem Cell Reviews and Reports. 17, 6, p. 2304-2313 10 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)
Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H. & Luo, N. & 12 others, , Dec 1 2020, In: Nature communications. 11, 1, 3856.Research output: Contribution to journal › Comment/debate › peer-review
Open Access