Cell-type specific risk and resilience in Alzheimer’s disease and aging

Project: Research project

Project Details


Alzheimer’s disease shows distinct progressive histological and behavioral hallmarks but its cell-type basis is not clear. Recent human postmortem studies begin to provide compelling rationale thatconstituent cell types bear a non-uniform risk profile, but the underlying cell specific progression ofvulnerabilities remain unknown. Through cross-disciplinary systems biology approaches we will identify thevulnerable subclass of cells in AD, establish cell-type specific AD signatures and further investigate biologicalrelationship between healthy aging and AD pathology.
Effective start/end date5/1/214/30/24


  • National Institute on Aging: $2,194,586.00


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.