Cell-type specific risk and resilience in Alzheimer’s disease and aging

Alzheimer’s disease shows distinct progressive histological and behavioral hallmarks but its cell-type basis is not clear. Recent human postmortem studies begin to provide compelling rationale thatconstituent cell types bear a non-uniform risk profile, but the underlying cell specific progression ofvulnerabilities remain unknown. Through cross-disciplinary systems biology approaches we will identify thevulnerable subclass of cells in AD, establish cell-type specific AD signatures and further investigate biologicalrelationship between healthy aging and AD pathology.