Cohort Differences in Cognitive Impairment and Alzheimer Disease and Related Dementias: Education Effects and Sex Differences

Project Narrative Reliable projection of the prevalence and incidence rates of cognitive impairment and Alzheimer's disease and related dementias (ADRD) proves to be difficult without assessing the relative contribution of population aging, cohort replacement, and period shifts. The proposed research will develop a novel method and analyze multi-cohort longitudinal datasets to identify cohort variations and sex differences in cognitive impairment and ADRD, and how the education effects vary between cohorts and sex groups. The proposed study is relevant to public health because the results will improve the detection and prevention of ADRD by elucidating how life-course exposures and experiences may modify pathways to the disease.