Project Details


PROJECT NARRATIVE JC polyomavirus (JCPyV), a prevalent human-only pathogen, causes life-threatening brain diseases in immunologically compromised individuals. The list of immunotherapeutic and chemotherapeutic agents linked to JCPyV CNS diseases is rapidly expanding; no anti-JCPyV agents are available. Using a mouse virus in the same family as JCPyV, we developed a tractable animal model to explore early stages in the pathogenesis of polyomavirus brain infections that precede development of irreversible lesions.
Effective start/end date5/1/161/31/23


  • National Institute of Neurological Disorders and Stroke: $336,252.00
  • National Institute of Neurological Disorders and Stroke: $430,944.00


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