Enzymatic Fluoroalkylation using Te-Adenosyl-Telluromethionine Analogs and Late-Stage Diversification of Natural Products Exhibiting Antibacterial Behavior

Project Narrative The proposed work focuses on the design and synthesis of fluoroalkyl group-carrying analogs of S- adenosylmethionine, and their use in performing regio- and stereoselective enzymatic fluoroalkylation. The work provides a novel approach for late stage fluoroalkylation, which enables facile derivatization of a wide range of antibacterial natural products.