Forced Oscillometry Technique to improve detection and management of pulmonary exacerbations in adults with cystic fibrosis

Our aims are to: 1. Evaluate the utility of FOT in the detection of changes in lung function in adult patients with CF during treatment of a PEx and to assess the magnitude and variability of change through their clinical journey. 2. Assess the effect of formal airway clearance on FOT during a PEx. 3. Compare FOT with routine clinical and laboratory lung function techniques. 4. Monitor changes in inflammation and microbiology to provide biological rationale to FOT measurements. 5. Assess patient satisfaction with the FOT as an investigation device. This will be a prospective, uni-centre study evaluating approximately 30 consecutive adult patients with CF treated for a PEx by the Adult Cystic Fibrosis Centre (ACFC) at The Prince Charles Hospital (PCH). Based on admission data over the past one year, I anticipate that there will be an even distribution of patients receiving CFTR modulator therapy versus those not receiving therapy. Current hospital standards of admission and therapy will be observed with FOT measurements taken intermittently throughout the treatment period.