Project Details
Description
Project Narrative
Herpes simplex virus 1 (HSV-1) is a globally prevalent pathogen with a large and negative public health
impact. Viral genetic differences likely impact the varied severity of disease outcomes seen in infected
individuals, but the contributions of naturally-occurring viral variations to disease are not yet known.
Using viral genome sequencing and phenotypic analysis in a murine ocular model of infection, we have
detected viral genetic loci that are associated with high- vs. low-virulence – this project will test these
virulence-gene associations, and their impacts on viral fitness and virulence.
Status | Finished |
---|---|
Effective start/end date | 2/23/18 → 1/31/23 |
Funding
- National Institute of Allergy and Infectious Diseases: $394,427.00
- National Institute of Allergy and Infectious Diseases: $421,991.00
- National Institute of Allergy and Infectious Diseases: $332,720.00
- National Institute of Allergy and Infectious Diseases: $392,768.00
- National Institute of Allergy and Infectious Diseases: $394,535.00
- National Institute of Allergy and Infectious Diseases: $394,482.00
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