Cancer Center Support Grant

ABSTRACT Holden Comprehensive Cancer Center (HCCC) at the University of Iowa (UI) is the only NCI designated cancer center in the state of Iowa, a highly rural state that serves as the HCCC catchment area. The HCCC leverages its highly collaborative culture to advance transdisciplinary, cancer research that is particularly relevant to the people of Iowa. This includes basic cancer research, a strong portfolio of translational multi-investigator grants including the nations only Specialized Program of Research Excellence (SPORE) P50 grant focused on Neuroendocrine Tumors, a new NCI P01 and population science research addressing prevention, cancer control and survivorship. HCCC has a growing portfolio of early phase clinical trials including studies based on discovery science emerging from the HCCC. The HCCC functions administratively as a matrix Cancer Center with 174 Center members from seven UI colleges. The members of the HCCC have $20.6 million in direct annual cancer-related, peer-reviewed, external research support. Of this, $11.0 million comes from the NCI. The HCCC is organized into three research programs. Cancer Genes and Pathways (CGP) is the basic science program of the HCCC. Experimental Redox Therapeutics (ERT) is the translational program, and Cancer Epidemiology and Population Science (CEPS) is a population science program. HCCC members benefit from seven HCCC managed shared resources including Biostatistics, Biospecimen Procurement & Molecular Epidemiology, Flow Cytometry, Genomics, Population Research, Radiation Free Radical Research, Viral Vector and one developing shared resource, Translational Immunology Core. The HCCC has a robust Community Outreach and Engagement effort that facilitates bidirectional interactions between the HCCC and the people of Iowa. It leverages the resources of the Iowa Cancer Consortium (ICC) and research infrastructure that extends into the community. It also has a comprehensive Career Enhancement (CE) Program. In summary, the HCCC provides a collaborative environment, infrastructure and resources to strengthen all aspects of interdisciplinary cancer research taking place at UI.