Narrative The goal of this project is to understand the role of HOXB locus-associated lncRNA, HOXBLINC, in hematopoietic stem cell regulation and leukemogenesis. Our studies will unveil the mechanisms by which HoxBlinc lncRNA fine-tune HOX gene activation and modulate hematopoietic stem cell behavior. Our project could identify a novel oncogenic lncRNA and therapeutic target for patients with HOX gene dysregulation.
|Effective start/end date
|1/15/19 → 12/31/22
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