Wnt/beta-catenin signaling in early-onset colorectal cancer

PROJECT SUMMARY Colorectal cancer (CRC) remains the third leading cause of cancer related deaths in the US. Although the over- all incidence is declining, the incidence in the younger population has been steadily increasing over the past thirty years. While a western diet and a sedentary lifestyle are among contributing environmental factors to early onset colorectal cancer (EOCRC; as defined in individuals