TY - JOUR
T1 - β-Funaltrexamine (β-FNA) and the regulation of body and brain development in rats
AU - Zagon, I. S.
AU - McLaughlin, P. J.
N1 - Funding Information:
We are gratefult o Ms. Susan Ditty for technicala ssistancea nd Ms. Doris Lineweaverf or manuscriptp reparationO. ur appreciation is extendedt o Drs. Portoghesea nd Takemori for reviewing the manuscript.T his research was supportedi n part by NIH grants NS-20623a nd NS-20500.
PY - 1986/7
Y1 - 1986/7
N2 - The effects of β-FNA, a highly selective and irreversible μ opioid receptor antagonist, in altering body and brain development in preweaning rats were determined. Animals given β-FNA did not differ from controls in body weights, brain and cerebellar weights, macroscopic dimensions of the brain, the area of the cerebellum, or in organ weight. The dosage of β-FNA utilized (5 mg/kg) blocked morphine-induced analgesia (2 mg/kg morphine sulfate, SC) for each injection period (i.e., 48 hr). In contrast to β-FNA treatment, rats given naltrexone (50 mg/kg SC) in a regimen which completely blocked the opioid receptor throughout ontogeny exhibited marked increases in somatic and neurobiological growth. These results suggest that, in and by themselves, μ receptors selectively antagonized by β-FNA do not play an important role in regulating development.
AB - The effects of β-FNA, a highly selective and irreversible μ opioid receptor antagonist, in altering body and brain development in preweaning rats were determined. Animals given β-FNA did not differ from controls in body weights, brain and cerebellar weights, macroscopic dimensions of the brain, the area of the cerebellum, or in organ weight. The dosage of β-FNA utilized (5 mg/kg) blocked morphine-induced analgesia (2 mg/kg morphine sulfate, SC) for each injection period (i.e., 48 hr). In contrast to β-FNA treatment, rats given naltrexone (50 mg/kg SC) in a regimen which completely blocked the opioid receptor throughout ontogeny exhibited marked increases in somatic and neurobiological growth. These results suggest that, in and by themselves, μ receptors selectively antagonized by β-FNA do not play an important role in regulating development.
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U2 - 10.1016/0361-9230(86)90155-3
DO - 10.1016/0361-9230(86)90155-3
M3 - Article
C2 - 3019487
AN - SCOPUS:0022471073
SN - 0361-9230
VL - 17
SP - 5
EP - 9
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 1
ER -