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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-Formyl-DDACTHF): A potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

  • Thomas H. Marsilje
  • , Marc A. Labroli
  • , Michael P. Hedrick
  • , Qing Jin
  • , Joel Desharnais
  • , Stephen J. Baker
  • , Lata T. Gooljarsingh
  • , Joseph Ramcharan
  • , Ali Tavassoli
  • , Yan Zhang
  • , Ian A. Wilson
  • , G. Peter Beardsley
  • , Stephen J. Benkovic
  • , Dale L. Boger

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