10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-Formyl-DDACTHF): A potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

Thomas H. Marsilje, Marc A. Labroli, Michael P. Hedrick, Qing Jin, Joel Desharnais, Stephen J. Baker, Lata T. Gooljarsingh, Joseph Ramcharan, Ali Tavassoli, Yan Zhang, Ian A. Wilson, G. Peter Beardsley, Stephen J. Benkovic, Dale L. Boger

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Pharmacology, Toxicology and Pharmaceutical Science

Biochemistry, Genetics and Molecular Biology

Chemistry

Immunology and Microbiology