1,25-dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

Margherita T. Cantorna; Colleen E. Hayes; Hector F. Deluca

doi:10.1073/pnas.93.15.7861

1,25-dihydroxyvitamin D₃ reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

Margherita T. Cantorna
, Colleen E. Hayes
, Hector F. Deluca

Research output: Contribution to journal › Article › peer-review

664 Scopus citations

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP). EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D₃ [1,25- (OH)₂D₃]. 1,25-(OH)₂D₃ could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)₂D₃ resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)₂D₃ is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)₂D₃ or its analogs are potentially important for treatment of MS.

Original language	English (US)
Pages (from-to)	7861-7864
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	93
Issue number	15
DOIs	https://doi.org/10.1073/pnas.93.15.7861
State	Published - Jul 23 1996

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title = "1,25-dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis",

abstract = "Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP). EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25- (OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.",

author = "Cantorna, \{Margherita T.\} and Hayes, \{Colleen E.\} and Deluca, \{Hector F.\}",

year = "1996",

month = jul,

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doi = "10.1073/pnas.93.15.7861",

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1,25-dihydroxyvitamin D₃ reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. / Cantorna, Margherita T.; Hayes, Colleen E.; Deluca, Hector F.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 15, 23.07.1996, p. 7861-7864.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 1,25-dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

AU - Cantorna, Margherita T.

AU - Hayes, Colleen E.

AU - Deluca, Hector F.

PY - 1996/7/23

Y1 - 1996/7/23

N2 - Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP). EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25- (OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.

AB - Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP). EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25- (OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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1,25-dihydroxyvitamin D₃ reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

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