1,6-C-H insertion of alkylidenecarbenes in 1-naphthol and 1-anthrol derivatives

Ken S. Feldman, Angela L. Perkins

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Rare 1,6-C-H insertion of naphthol- and anthrol-derived alkylidenecarbenes has been observed in modest yield. Reaction in deuterated solvent did not provide any evidence in support of a reaction mechanism that requires exchange of the migrating proton with solvent. The pyran-annelated aromatic products are formed only when opportunities for the more common 1,5-C-H insertion process are blocked.

Original languageEnglish (US)
Pages (from-to)6031-6033
Number of pages3
JournalTetrahedron Letters
Issue number35
StatePublished - Aug 27 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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