TY - GEN
T1 - 19.3 A MEMS-Based Dynamic Light Focusing System for Single-Cell Precision in optogenetics
AU - Yalcin, Cem
AU - Ersumo, Nathan Tessema
AU - Bocchetti, George
AU - Ghanbari, Mohammad Meraj
AU - Antipa, Nick
AU - Alamouti, Sina Faraji
AU - Waller, Laura
AU - Lopez, Daniel
AU - Muller, Rikky
N1 - Funding Information:
The authors thank the sponsors of the Berkeley Wireless Research Center (BWRC), the TSMC University Shuttle Program for chip fabrication, and Prof. Ming Wu. This work was funded by Chan Zuckerberg Biohub and the McKnight Technological Innovations in Neuroscience Award.
Publisher Copyright:
© 2021 IEEE.
PY - 2021/2/13
Y1 - 2021/2/13
N2 - Optogenetics is a technique that involves the use of light to excite or inhibit neurons that have been genetically modified to express light-sensitive ion channels (opsins). Implanted LEDs or optical fibers are the most common approaches in optogenetic stimulation systems, but their broad illumination and lack of beam steering capability make them insufficient for probing individual neurons. When a 3D scanning optical system is used to control the position of a laser spot, single-cell precision can be achieved in a volume of tissue containing millions of cells. Due to the sub-ms response time of modern opsins and a demand for high throughput neural stimulation [1], a random-access scanning system requires a kHz refresh rate, and the capability to dwell on a target depth for an arbitrary length of time. Existing lateral (XY) scanning tools are fast, however state-of-the-art axial (Z) scanning technologies such as electrically tunable lenses (ETLs) [2] and liquid crystal (LC) lenses [3] are limited to < 3ms settling times. Alternative axial scanning tools either lack dwelling capability [4] or have impractical actuator drive requirements [5].
AB - Optogenetics is a technique that involves the use of light to excite or inhibit neurons that have been genetically modified to express light-sensitive ion channels (opsins). Implanted LEDs or optical fibers are the most common approaches in optogenetic stimulation systems, but their broad illumination and lack of beam steering capability make them insufficient for probing individual neurons. When a 3D scanning optical system is used to control the position of a laser spot, single-cell precision can be achieved in a volume of tissue containing millions of cells. Due to the sub-ms response time of modern opsins and a demand for high throughput neural stimulation [1], a random-access scanning system requires a kHz refresh rate, and the capability to dwell on a target depth for an arbitrary length of time. Existing lateral (XY) scanning tools are fast, however state-of-the-art axial (Z) scanning technologies such as electrically tunable lenses (ETLs) [2] and liquid crystal (LC) lenses [3] are limited to < 3ms settling times. Alternative axial scanning tools either lack dwelling capability [4] or have impractical actuator drive requirements [5].
UR - http://www.scopus.com/inward/record.url?scp=85102388946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102388946&partnerID=8YFLogxK
U2 - 10.1109/ISSCC42613.2021.9365792
DO - 10.1109/ISSCC42613.2021.9365792
M3 - Conference contribution
AN - SCOPUS:85102388946
T3 - Digest of Technical Papers - IEEE International Solid-State Circuits Conference
SP - 290
EP - 292
BT - 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021
Y2 - 13 February 2021 through 22 February 2021
ER -