2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells

William Plunkett; Varsha Gandhi; Sherri Chubb; Billie Nowak; Volker Heinemann; Shin Mineishi; Alina Sen

doi:10.1080/07328318908054215

2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells

William Plunkett
, Varsha Gandhi
, Sherri Chubb
, Billie Nowak
, Volker Heinemann
, Shin Mineishi
, Alina Sen

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

The toxicity of 2', 2'-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.

Original language	English (US)
Pages (from-to)	775-785
Number of pages	11
Journal	Nucleosides and Nucleotides
Volume	8
Issue number	5-6
DOIs	https://doi.org/10.1080/07328318908054215
State	Published - Jan 1 1989

All Science Journal Classification (ASJC) codes

Biochemistry
Genetics

Access to Document

10.1080/07328318908054215

Cite this

@article{0d4a97e34b294c598774ae9703a42cb8,

title = "2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells",

abstract = "The toxicity of 2', 2'-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.",

author = "William Plunkett and Varsha Gandhi and Sherri Chubb and Billie Nowak and Volker Heinemann and Shin Mineishi and Alina Sen",

note = "Funding Information: ACKNOWLEDGMENT. This investigation was supported in part by grant CA28596 from the National Institutes of Health, DHHS, and grant CH-130 from the American Cancer Society.",

year = "1989",

month = jan,

day = "1",

doi = "10.1080/07328318908054215",

language = "English (US)",

volume = "8",

pages = "775--785",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

publisher = "Marcel Dekker Inc.",

number = "5-6",

}

TY - JOUR

T1 - 2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells

AU - Plunkett, William

AU - Gandhi, Varsha

AU - Chubb, Sherri

AU - Nowak, Billie

AU - Heinemann, Volker

AU - Mineishi, Shin

AU - Sen, Alina

N1 - Funding Information: ACKNOWLEDGMENT. This investigation was supported in part by grant CA28596 from the National Institutes of Health, DHHS, and grant CH-130 from the American Cancer Society.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The toxicity of 2', 2'-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.

AB - The toxicity of 2', 2'-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.

UR - https://www.scopus.com/pages/publications/0024359547

UR - https://www.scopus.com/pages/publications/0024359547#tab=citedBy

U2 - 10.1080/07328318908054215

DO - 10.1080/07328318908054215

M3 - Article

AN - SCOPUS:0024359547

SN - 0732-8311

VL - 8

SP - 775

EP - 785

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 5-6

ER -

2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this