TY - JOUR
T1 - 2-Deoxy-D-glucose produces delayed hypophagia and conditioned taste aversion in rats
AU - Thompson, Carl I.
AU - Zagon, Ian S.
N1 - Funding Information:
Twenty male and 19 female Sprague-Dawley rats were tested. These animals were born in our laboratory and were first-generation offspring of stock obtained from Charles 1This research was supported by National Institute on Drug Abuse Grant DA 01618. Victoria Kepp and Paticia McLaughlin provided valuable technical assistance. 2Send reprint requests to Carl I. Thompson, Ph.D., Department of Behavioral Science, The M.S. Hershey Medical Center, Hershey, PA 17033.
PY - 1981/12
Y1 - 1981/12
N2 - The glucose analogue 2-deoxy-D-glucose (2DG) produces cellular glucoprivation and a brief (1-6 hr) hyperphagia that may be followed by a period of overcompensatory hypophagia in rats. The present study examined the dose-response effects of 2DG upon food intake at 1, 6, and 24 hr, and investigated whether taste aversions are formed for a substance consumed immediately prior to drug injection. Water-deprived rats drank a novel 0.2% saccharin solution and then received a single injection of either 2DG (250, 500, or 750 mg/kg, IP) or saline. Food intake was elevated equally by all 2 DG doses at 1 hr, but by 6 hr these elevations no longer were statistically significant. At 24 hr, intake was subnormal after 750 mg/kg but normal after the lower doses. Conditioned saccharin aversions, measured 4 and 5 days after drug injection using 2-bottle preference tests, were produced by all 2DG doses and were not dose-related. It is suggested that the depression of 24-hr food intake that occurs after high doses may not be caused by the same drug property that induces taste aversion.
AB - The glucose analogue 2-deoxy-D-glucose (2DG) produces cellular glucoprivation and a brief (1-6 hr) hyperphagia that may be followed by a period of overcompensatory hypophagia in rats. The present study examined the dose-response effects of 2DG upon food intake at 1, 6, and 24 hr, and investigated whether taste aversions are formed for a substance consumed immediately prior to drug injection. Water-deprived rats drank a novel 0.2% saccharin solution and then received a single injection of either 2DG (250, 500, or 750 mg/kg, IP) or saline. Food intake was elevated equally by all 2 DG doses at 1 hr, but by 6 hr these elevations no longer were statistically significant. At 24 hr, intake was subnormal after 750 mg/kg but normal after the lower doses. Conditioned saccharin aversions, measured 4 and 5 days after drug injection using 2-bottle preference tests, were produced by all 2DG doses and were not dose-related. It is suggested that the depression of 24-hr food intake that occurs after high doses may not be caused by the same drug property that induces taste aversion.
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U2 - 10.1016/0031-9384(81)90361-9
DO - 10.1016/0031-9384(81)90361-9
M3 - Article
C2 - 7335800
AN - SCOPUS:0019751386
SN - 0031-9384
VL - 27
SP - 1001
EP - 1004
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 6
ER -