TY - JOUR
T1 - 24-Month outcomes of primary care web-based depression prevention intervention in adolescents
T2 - Randomized clinical trial
AU - van Voorhees, Benjamin
AU - Gladstone, Tracy R.G.
AU - Sobowale, Kunmi
AU - Brown, C. Hendricks
AU - Aaby, David A.
AU - Terrizzi, Daniela A.
AU - Canel, Jason
AU - Ching, Eumene
AU - Berry, Anita D.
AU - Cantorna, James
AU - Eder, Milton
AU - Beardslee, William
AU - Fitzgibbon, Marian
AU - Marko-Holguin, Monika
AU - Schiffer, Linda
AU - Lee, Miae
AU - de Forest, Sarah A.
AU - Sykes, Emily E.
AU - Suor, Jennifer H.
AU - Crawford, Theodore J.
AU - Burkhouse, Katie L.
AU - Goodwin, Brady C.
AU - Bell, Carl
N1 - Publisher Copyright:
©Benjamin Van Voorhees, Tracy R G Gladstone, Kunmi Sobowale, C Hendricks Brown, David A Aaby, Daniela A Terrizzi, Jason Canel, Eumene Ching, Anita D Berry, James Cantorna, Milton Eder, William Beardslee, Marian Fitzgibbon, Monika Marko-Holguin, Linda Schiffer, Miae Lee, Sarah A de Forest, Emily E Sykes, Jennifer H Suor, Theodore J Crawford, Katie L Burkhouse, Brady C Goodwin, Carl Bell.
PY - 2020/10
Y1 - 2020/10
N2 - Background: Adolescent depression carries a high burden of disease worldwide, but access to care for this population is limited. Prevention is one solution to curtail the negative consequences of adolescent depression. Internet interventions to prevent adolescent depression can overcome barriers to access, but few studies examine long-term outcomes. Objective: This study compares CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training), an internet-based intervention, to a general health education active control for depression onset at 12 and 24 months in adolescents presenting to primary care settings. Methods: A 2-site randomized trial, blinded to the principal investigators and assessors, was conducted comparing Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training to health education to prevent depressive episodes in 369 adolescents (193 youths were randomly assigned to Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training and 176 to health education) with subthreshold depressive symptoms or prior depressive episodes. Participants were recruited from primary care settings in the United States. The primary outcome was the occurrence of a depressive episode, determined by the Depression Symptom Rating. The secondary outcome was functioning, measured by the Global Assessment Scale. Results: In intention-to-treat analyses, the adjusted hazard ratio favoring Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training for first depressive episode was not statistically significant at 12 months (hazard ratio 0.77, 95% CI 0.42-1.40, P=.39) and 24 months (hazard ratio 0.87, 95% CI 0.52-1.47, P=.61). Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training provided preventive benefit for first depressive episode for those with mild hopelessness or at least moderate paternal monitoring at baseline. Global Assessment Scale scores improved comparably in both groups (intention-to-treat). Conclusions: A technology-based intervention for adolescent depression prevention implemented in primary care did not have additional benefit at 12 or 24 months. Further research is necessary to determine whether internet interventions have long-term benefit.
AB - Background: Adolescent depression carries a high burden of disease worldwide, but access to care for this population is limited. Prevention is one solution to curtail the negative consequences of adolescent depression. Internet interventions to prevent adolescent depression can overcome barriers to access, but few studies examine long-term outcomes. Objective: This study compares CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training), an internet-based intervention, to a general health education active control for depression onset at 12 and 24 months in adolescents presenting to primary care settings. Methods: A 2-site randomized trial, blinded to the principal investigators and assessors, was conducted comparing Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training to health education to prevent depressive episodes in 369 adolescents (193 youths were randomly assigned to Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training and 176 to health education) with subthreshold depressive symptoms or prior depressive episodes. Participants were recruited from primary care settings in the United States. The primary outcome was the occurrence of a depressive episode, determined by the Depression Symptom Rating. The secondary outcome was functioning, measured by the Global Assessment Scale. Results: In intention-to-treat analyses, the adjusted hazard ratio favoring Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training for first depressive episode was not statistically significant at 12 months (hazard ratio 0.77, 95% CI 0.42-1.40, P=.39) and 24 months (hazard ratio 0.87, 95% CI 0.52-1.47, P=.61). Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training provided preventive benefit for first depressive episode for those with mild hopelessness or at least moderate paternal monitoring at baseline. Global Assessment Scale scores improved comparably in both groups (intention-to-treat). Conclusions: A technology-based intervention for adolescent depression prevention implemented in primary care did not have additional benefit at 12 or 24 months. Further research is necessary to determine whether internet interventions have long-term benefit.
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U2 - 10.2196/16802
DO - 10.2196/16802
M3 - Article
C2 - 33112254
AN - SCOPUS:85094812459
SN - 1439-4456
VL - 22
JO - Journal of medical Internet research
JF - Journal of medical Internet research
IS - 10
M1 - e16802
ER -