TY - JOUR
T1 - 25(OH)D 3 and cardiovascular risk factors in female nonhuman primates
AU - Jorgensen, Matthew J.
AU - Rudel, Lawrence L.
AU - Nudy, Matthew
AU - Kaplan, Jay R.
AU - Clarkson, Thomas B.
AU - Pajewski, Nicholas M.
AU - Schnatz, Peter F.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Objective: To determine if interindividual differences in plasma concentrations of 25-hydroxyvitamin D 3 (25(OH)D 3) have pathophysiologic significance, we evaluated a cohort of female monkeys, seeking to identify associations with clinically relevant cardiovascular risk factors, including age, abdominal obesity (waist circumference), and high-density lipoprotein cholesterol (HDL-C). Methods: One hundred fifty-five female vervet monkeys (Chlorocebus aethiops sabaeus) aged 3-25 years consumed a typical western diet for 7-8 weeks that provided a woman's equivalent of approximately 1000 IU/day of vitamin D 3. Measurements of vitamin D 3 and HDL-C concentrations, as well as waist circumference, were obtained. Results: Among young monkeys (aged 3-5 years), compared to older monkeys (aged 16-25 years), the mean plasma 25(OH)D 3 concentrations were 82.3±3.2 ng/mL and 58.6±2.9 ng/mL (p<0.0001), respectively. Plasma 25(OH)D 3 concentrations had a range of 19.6-142.0 ng/mL (mean± standard error [SE] 66.4±1.7 ng/mL). 25(OH)D 3 concentrations were inversely associated with age (p<0.0001) and waist circumference (p=0.016) and were positively correlated with HDL-C (p=0.01). However, when statistically controlling for age, none of these relationships remained significant. Conclusions: Higher plasma concentrations of 25(OH)D 3 were associated with more favorable cardiovascular risk factors, with inverse associations observed between 25(OH)D 3 and abdominal obesity, HDL-C, and age. These associations were no longer significant when controlling for age.
AB - Objective: To determine if interindividual differences in plasma concentrations of 25-hydroxyvitamin D 3 (25(OH)D 3) have pathophysiologic significance, we evaluated a cohort of female monkeys, seeking to identify associations with clinically relevant cardiovascular risk factors, including age, abdominal obesity (waist circumference), and high-density lipoprotein cholesterol (HDL-C). Methods: One hundred fifty-five female vervet monkeys (Chlorocebus aethiops sabaeus) aged 3-25 years consumed a typical western diet for 7-8 weeks that provided a woman's equivalent of approximately 1000 IU/day of vitamin D 3. Measurements of vitamin D 3 and HDL-C concentrations, as well as waist circumference, were obtained. Results: Among young monkeys (aged 3-5 years), compared to older monkeys (aged 16-25 years), the mean plasma 25(OH)D 3 concentrations were 82.3±3.2 ng/mL and 58.6±2.9 ng/mL (p<0.0001), respectively. Plasma 25(OH)D 3 concentrations had a range of 19.6-142.0 ng/mL (mean± standard error [SE] 66.4±1.7 ng/mL). 25(OH)D 3 concentrations were inversely associated with age (p<0.0001) and waist circumference (p=0.016) and were positively correlated with HDL-C (p=0.01). However, when statistically controlling for age, none of these relationships remained significant. Conclusions: Higher plasma concentrations of 25(OH)D 3 were associated with more favorable cardiovascular risk factors, with inverse associations observed between 25(OH)D 3 and abdominal obesity, HDL-C, and age. These associations were no longer significant when controlling for age.
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U2 - 10.1089/jwh.2011.3416
DO - 10.1089/jwh.2011.3416
M3 - Article
C2 - 22876774
AN - SCOPUS:84865735239
SN - 1540-9996
VL - 21
SP - 959
EP - 965
JO - Journal of Women's Health
JF - Journal of Women's Health
IS - 9
ER -