TY - JOUR
T1 - 3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering
AU - Moncal, Kazim K.
AU - Heo, Dong N.
AU - Godzik, Kevin P.
AU - Sosnoski, Donna M.
AU - Mrowczynski, Oliver D.
AU - Rizk, Elias
AU - Ozbolat, Veli
AU - Tucker, Scott M.
AU - Gerhard, Ethan M.
AU - Dey, Madhuri
AU - Lewis, Gregory S.
AU - Yang, Jian
AU - Ozbolat, Ibrahim T.
N1 - Publisher Copyright:
© Materials Research Society 2018.
PY - 2018/7/27
Y1 - 2018/7/27
N2 - Three-dimensional (3D) printing technology is a promising method for bone tissue engineering applications. For enhanced bone regeneration, it is important to have printable ink materials with appealing properties such as construct interconnectivity, mechanical strength, controlled degradation rates, and the presence of bioactive materials. In this respect, we develop a composite ink composed of polycaprolactone (PCL), poly(D,L-lactide-co-glycolide) (PLGA), and hydroxyapatite particles (HAps) and 3D print it into porous constructs. In vitro study revealed that composite constructs had higher mechanical properties, surface roughness, quicker degradation profile, and cellular behaviors compared to PCL counterparts. Furthermore, in vivo results showed that 3D-printed composite constructs had a positive influence on bone regeneration due to the presence of newly formed mineralized bone tissue and blood vessel formation. Therefore, 3D printable ink made of PCL/PLGA/HAp can be a highly useful material for 3D printing of bone tissue constructs.
AB - Three-dimensional (3D) printing technology is a promising method for bone tissue engineering applications. For enhanced bone regeneration, it is important to have printable ink materials with appealing properties such as construct interconnectivity, mechanical strength, controlled degradation rates, and the presence of bioactive materials. In this respect, we develop a composite ink composed of polycaprolactone (PCL), poly(D,L-lactide-co-glycolide) (PLGA), and hydroxyapatite particles (HAps) and 3D print it into porous constructs. In vitro study revealed that composite constructs had higher mechanical properties, surface roughness, quicker degradation profile, and cellular behaviors compared to PCL counterparts. Furthermore, in vivo results showed that 3D-printed composite constructs had a positive influence on bone regeneration due to the presence of newly formed mineralized bone tissue and blood vessel formation. Therefore, 3D printable ink made of PCL/PLGA/HAp can be a highly useful material for 3D printing of bone tissue constructs.
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U2 - 10.1557/jmr.2018.111
DO - 10.1557/jmr.2018.111
M3 - Article
AN - SCOPUS:85049298960
SN - 0884-2914
VL - 33
SP - 1972
EP - 1986
JO - Journal of Materials Research
JF - Journal of Materials Research
IS - 14
ER -