3dRNA v2.0: An updated web server for RNA 3D structure prediction

Jun Wang, Jian Wang, Yanzhao Huang, Yi Xiao

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

3D structures of RNAs are the basis for understanding their biological functions. However, experimentally solved RNA 3D structures are very limited in comparison with known RNA sequences up to now. Therefore, many computational methods have been proposed to solve this problem, including our 3dRNA. In recent years, 3dRNA has been greatly improved by adding several important features, including structure sampling, structure ranking and structure optimization under residue-residue restraints. Particularly, the optimization procedure with restraints enables 3dRNA to treat pseudoknots in a new way. These new features of 3dRNA can greatly promote its performance and have been integrated into the 3dRNA v2.0 web server. Here we introduce these new features in the 3dRNA v2.0 web server for the users.

Original languageEnglish (US)
Article number4116
JournalInternational journal of molecular sciences
Volume20
Issue number17
DOIs
StatePublished - Sep 1 2019

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of '3dRNA v2.0: An updated web server for RNA 3D structure prediction'. Together they form a unique fingerprint.

Cite this