@article{d36be3e806cb41cdb3980b48fd9c0c9e,
title = "5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents",
abstract = "Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) is essential for the exflagellation of male gametocytes. Inhibition of PfCDPK4 is an effective way of blocking the transmission of malaria by mosquitoes. A series of 5-aminopyrazole-4-carboxamide analogues are demonstrated to be potent inhibitors of PfCDPK4. The compounds are also able to block exflagellation of Plasmodium falciparum male gametocytes without observable toxicity to mammalian cells.",
author = "Wenlin Huang and Hulverson, {Matthew A.} and Zhongsheng Zhang and Ryan Choi and Hart, {Kevin J.} and Mark Kennedy and Vidadala, {Rama Subba Rao} and Maly, {Dustin J.} and {Van Voorhis}, {Wesley C.} and Lindner, {Scott E.} and Erkang Fan and Ojo, {Kayode K.}",
note = "Funding Information: Research work described in this study was supported by the National Institute of Allergy and Infectious Diseases and National Institute of Child Health and Human Development of the National Institutes of Health under the award numbers R01AI089441 , R01AI111341 , and R01HD080670 , and by start-up funds from the Pennsylvania State University. The work was also supported by awards # 2014-06183 from the United States Department of Agriculture National Institute of Food and Agriculture . Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2016",
doi = "10.1016/j.bmcl.2016.10.014",
language = "English (US)",
volume = "26",
pages = "5487--5491",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "22",
}