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8-hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions
Keith Cheng
, D. S. Cahill
, H. Kasai
, S. Nishimura
, L. A. Loeb
Department of Pathology and Laboratory Medicine
Penn State Cancer Institute
Huck Institutes of the Life Sciences
Cancer Institute, Next-Generation Therapies
Division of Experimental Pathology
Institute for Computational and Data Sciences (ICDS)
Department of Molecular and Precision Medicine
Research output
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Contribution to journal
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Article
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peer-review
1806
Scopus citations
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Dive into the research topics of '8-hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions'. Together they form a unique fingerprint.
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Keyphrases
8-hydroxyguanine
100%
Bacteriophage
33%
Base Pairing
33%
Bioassay Test
33%
C Substitution
100%
Causes of Damage
100%
DNA Polymerase
33%
Forward mutation Assay
33%
Gap Region
33%
Guanine Analogues
33%
Human Disease
33%
Misincorporation
33%
Mispair
33%
Mispairing
33%
Misreading
33%
Mutation Frequency
33%
Oxidative DNA Damage
100%
Plaque
33%
Single-base Substitution
33%
Single-stranded DNA (ssDNA)
33%
SsDNA Gaps
33%
Biochemistry, Genetics and Molecular Biology
Bacteriophage
50%
Base Pairing
50%
DNA Damage
100%
DNA Polymerase
50%
DNA Template
50%
Guanine
50%
Mutation Rate
50%
Nucleic Acid Base Substitution
50%
Revertant
50%
Single-Stranded DNA
50%