TY - JOUR
T1 - A 7 tesla fMRI study of amygdala responses to fearful faces
AU - Van Der Zwaag, Wietske
AU - Da Costa, Sandra E.
AU - Zürcher, Nicole R.
AU - Adams, Reginald B.
AU - Hadjikhani, Nouchine
N1 - Funding Information:
Acknowledgments This work was supported by grant FNS PP00P3_130191 to NH, by the Centre d′Imagerie BioMédicale (CIBM) of the University of Lausanne (UNIL), the Swiss Federal Institute of Technology Lausanne (EPFL), the University of Geneva (UniGe), the Centre Hospitalier Universitaire Vaudois (CHUV), the Hôpitaux Universitaires de Genève (HUG) and the Leenaards and the Jeantet Foundations.
PY - 2012/4
Y1 - 2012/4
N2 - The amygdalae are involved in the perception of emotions such as happiness, anger and fear. Because of their proximity to the sinuses, the image signal intensity in T2*weighted fMRI data is often affected by signal loss due to through-slice dephasing, especially at high field strength. In this study, the feasibility of fMRI in the amygdalae at 7 Tesla was investigated. A paradigm based on the presentation of fearful faces was used for stimulation. Previously, opposite effects have been found for presentation of averted and direct gaze fearful faces. Here, we show that (1) sufficiently high temporal SNR values are reached in the amygdalae for detection of small BOLD signal changes and (2) that the BOLD signal in the amygdalae for presentation of a direct or averted gaze in a fearful face depends on stimulus duration.
AB - The amygdalae are involved in the perception of emotions such as happiness, anger and fear. Because of their proximity to the sinuses, the image signal intensity in T2*weighted fMRI data is often affected by signal loss due to through-slice dephasing, especially at high field strength. In this study, the feasibility of fMRI in the amygdalae at 7 Tesla was investigated. A paradigm based on the presentation of fearful faces was used for stimulation. Previously, opposite effects have been found for presentation of averted and direct gaze fearful faces. Here, we show that (1) sufficiently high temporal SNR values are reached in the amygdalae for detection of small BOLD signal changes and (2) that the BOLD signal in the amygdalae for presentation of a direct or averted gaze in a fearful face depends on stimulus duration.
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U2 - 10.1007/s10548-012-0219-0
DO - 10.1007/s10548-012-0219-0
M3 - Article
C2 - 22270846
AN - SCOPUS:84862750731
SN - 0896-0267
VL - 25
SP - 125
EP - 128
JO - Brain Topography
JF - Brain Topography
IS - 2
ER -