TY - JOUR
T1 - A biochemical analysis of thoracic neuroblastomas
T2 - A pediatric oncology group study
AU - Shochat, Stephen J.
AU - Corbelletta, Nancy L.
AU - Repman, Mary Ann
AU - Schengrund, Cara Lynne
N1 - Funding Information:
From the Division of Pediatric Surgery, Stanford University Medical Center, Stanford, CA, and the Department of Biological Chemistry, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey. Supported in part by Grant Nos. CA 14319, CA 33603, CA 29139, and CA 30969from the National Cancer Institute. Presented at the 35th Annual Meeting of the Surgical Section of the American Academy of Pediatrics, Washington, DC, November 1-2, 1986. Address reprint requests to Stephen J. Shochat, MD, (POG-8105), Pediatric Oncology Group, 2nd Floor, Suite A, 4949 W Pine Blvd, St Louis, MO 63108. 9 1987 by Grune & Stratton, Inc. 0022-3468/87/2207-0020503.00/0
PY - 1987/7
Y1 - 1987/7
N2 - A biochemical analysis was performed on tumor tissuesfrom 20 patients who presented with thoracic neuroblastomas. Nine patients were under 1 year of age at the time of diagnosis, and 12 patients had stage A disease. Eighteen of the 20 patients are disease free with a mean follow-up of 51/2 years. The ganglioside composition of the tumor tissue was investigated, since these cell membrane components have been proposed to play a role in cell to cell interaction and may be altered on cell transformation. In addition, the ganglioside composition of the central nervous system changes with maturation. Previous studies in children with neuroblastoma have shown that tumor tissue containing more complex gangliosides is associated with a better prognosis. Neuroblastomas from patients with thoracic primaries were found to contain more complex gangliosides of the b series (GD1b, GT1b) and fewer monosialogangliosides, suggesting a more differentiated cellular composition. Tissue from one of the thoracic patients who died lacked GT1b. The absence of this ganglioside has proven to be an indicator of a poor prognosis. Four specimens contained no detectable GD2, which is thought to be a specific marker for neuroblastomas. These data suggest that the improved prognosis seen with thoracic neuroblas-tomas is due to a basic biologic difference within these tumors, and this finding should be taken into consideration when planning therapy.
AB - A biochemical analysis was performed on tumor tissuesfrom 20 patients who presented with thoracic neuroblastomas. Nine patients were under 1 year of age at the time of diagnosis, and 12 patients had stage A disease. Eighteen of the 20 patients are disease free with a mean follow-up of 51/2 years. The ganglioside composition of the tumor tissue was investigated, since these cell membrane components have been proposed to play a role in cell to cell interaction and may be altered on cell transformation. In addition, the ganglioside composition of the central nervous system changes with maturation. Previous studies in children with neuroblastoma have shown that tumor tissue containing more complex gangliosides is associated with a better prognosis. Neuroblastomas from patients with thoracic primaries were found to contain more complex gangliosides of the b series (GD1b, GT1b) and fewer monosialogangliosides, suggesting a more differentiated cellular composition. Tissue from one of the thoracic patients who died lacked GT1b. The absence of this ganglioside has proven to be an indicator of a poor prognosis. Four specimens contained no detectable GD2, which is thought to be a specific marker for neuroblastomas. These data suggest that the improved prognosis seen with thoracic neuroblas-tomas is due to a basic biologic difference within these tumors, and this finding should be taken into consideration when planning therapy.
UR - https://www.scopus.com/pages/publications/0023278203
UR - https://www.scopus.com/pages/publications/0023278203#tab=citedBy
U2 - 10.1016/S0022-3468(87)80122-7
DO - 10.1016/S0022-3468(87)80122-7
M3 - Article
C2 - 3612463
AN - SCOPUS:0023278203
SN - 0022-3468
VL - 22
SP - 660
EP - 664
JO - Journal of pediatric surgery
JF - Journal of pediatric surgery
IS - 7
ER -