A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel

Jian Yang, Delara Motlagh, Antonio R. Webb, Guillermo A. Ameer

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A biphasic scaffold that recapitulates smooth muscle cell (SMC) compartmentalization in a tissue engineered construct was fabricated. A newly developed biodegradable elastomeric polyester, poly(diol-co-citrate) was investigated for use as a scaffold material. The biphasic scaffold consists of a solid, continuous phase enabling the formation of a monolayer of endothelia cells (EC) within the vessel lumen. The scaffold was subjected to various characterization, including burst pressure as well as co-culture with SMC and EC. The results suggest that a biphasic scaffold design based on poly(diol-co-citrate) is a viable strategy towards the engineering of small diameter blood vessels.

Original languageEnglish (US)
Title of host publication2004 AIChE Annual Meeting, Conference Proceedings
Number of pages3
StatePublished - 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004


Other2004 AIChE Annual Meeting
Country/TerritoryUnited States
CityAustin, TX

All Science Journal Classification (ASJC) codes

  • General Engineering


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