Abstract
A biphasic scaffold that recapitulates smooth muscle cell (SMC) compartmentalization in a tissue engineered construct was fabricated. A newly developed biodegradable elastomeric polyester, poly(diol-co-citrate) was investigated for use as a scaffold material. The biphasic scaffold consists of a solid, continuous phase enabling the formation of a monolayer of endothelia cells (EC) within the vessel lumen. The scaffold was subjected to various characterization, including burst pressure as well as co-culture with SMC and EC. The results suggest that a biphasic scaffold design based on poly(diol-co-citrate) is a viable strategy towards the engineering of small diameter blood vessels.
| Original language | English (US) |
|---|---|
| Title of host publication | 2004 AIChE Annual Meeting, Conference Proceedings |
| Pages | 8333-8335 |
| Number of pages | 3 |
| State | Published - 2004 |
| Event | 2004 AIChE Annual Meeting - Austin, TX, United States Duration: Nov 7 2004 → Nov 12 2004 |
Other
| Other | 2004 AIChE Annual Meeting |
|---|---|
| Country/Territory | United States |
| City | Austin, TX |
| Period | 11/7/04 → 11/12/04 |
All Science Journal Classification (ASJC) codes
- General Engineering