TY - JOUR
T1 - A brain–heart biomarker for epileptogenesis
AU - Bahari, Fatemeh
AU - Ssentongo, Paddy
AU - Schiff, Steven J.
AU - Gluckman, Bruce J.
N1 - Funding Information:
This work was supported by Pennsylvania State Institute for the Neuroscience from Pennsylvania Department of Health Tobacco Funds, a Multidisciplinary Grant from Citizens United for Research in Epilepsy (CURE), National Institute of Health Grant R01EB019804, and a doctoral Academic Computing Fellowship from Pennsylvania State University to F.B. We thank Ali Nabi, Balaji Shanmugasundaram, and Myles W. Billard for assistance in development of the acquisition electronics and recording electrodes.
Funding Information:
ThisworkwassupportedbyPennsylvaniaStateInstitutefortheNeurosciencefromPennsylvaniaDepartmentof Health Tobacco Funds, a Multidisciplinary Grant from Citizens United for Research in Epilepsy (CURE), National Institute of Health Grant R01EB019804, and a doctoral Academic Computing Fellowship from Pennsylvania State UniversitytoF.B.WethankAliNabi,BalajiShanmugasundaram,andMylesW.Billardforassistanceindevelopment of the acquisition electronics and recording electrodes.
Publisher Copyright:
© 2018 the authors.
PY - 2018/9/26
Y1 - 2018/9/26
N2 - Postinjury epilepsy is an potentially preventable sequela in as many as 20% of patients with brain insults. For these cases biomarkers of epileptogenesis are critical to facilitate identification of patients at high-risk of developing epilepsy and to introduce effective anti-epileptogenic interventions. Here, we demonstrate that delayed brain–heart coincidences serve as a reliable biomarker. In a murine model of post-infection acquired epilepsy, we used long-term simultaneous measurements of the brain activity via electroencephalography and autonomic cardiac activity via electrocardiography, in male mice, to quantitatively track brain–heart interactions during epileptogenesis. We find that abnormal cortical discharges precede abnormal fluctuations in the cardiac rhythm at the resolution of single beat-to-beat intervals. The delayed brain–heart coincidence is detectable as early as the onset of chronic measurements, 2–14 weeks before the first seizure, only in animals that become epileptic, and increases during epileptogenesis. Therefore, delayed brain– heart coincidence serves as a biomarker of epileptogenesis and could be used for phenotyping, diagnostic, and therapeutic purposes.
AB - Postinjury epilepsy is an potentially preventable sequela in as many as 20% of patients with brain insults. For these cases biomarkers of epileptogenesis are critical to facilitate identification of patients at high-risk of developing epilepsy and to introduce effective anti-epileptogenic interventions. Here, we demonstrate that delayed brain–heart coincidences serve as a reliable biomarker. In a murine model of post-infection acquired epilepsy, we used long-term simultaneous measurements of the brain activity via electroencephalography and autonomic cardiac activity via electrocardiography, in male mice, to quantitatively track brain–heart interactions during epileptogenesis. We find that abnormal cortical discharges precede abnormal fluctuations in the cardiac rhythm at the resolution of single beat-to-beat intervals. The delayed brain–heart coincidence is detectable as early as the onset of chronic measurements, 2–14 weeks before the first seizure, only in animals that become epileptic, and increases during epileptogenesis. Therefore, delayed brain– heart coincidence serves as a biomarker of epileptogenesis and could be used for phenotyping, diagnostic, and therapeutic purposes.
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U2 - 10.1523/JNEUROSCI.1130-18.2018
DO - 10.1523/JNEUROSCI.1130-18.2018
M3 - Article
C2 - 30150365
AN - SCOPUS:85054129020
SN - 0270-6474
VL - 38
SP - 8473
EP - 8483
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 39
ER -