A calcium-permeable cGMP-activated cation conductance in hippocampal neurons

Trese Leinders-Zufall; Hendrik Rosenboom; Colin J. Barnstable; Gordon M. Shepherd; Frank Zufall

doi:10.1097/00001756-199509000-00013

A calcium-permeable cGMP-activated cation conductance in hippocampal neurons

Trese Leinders-Zufall, Hendrik Rosenboom, Colin J. Barnstable, Gordon M. Shepherd, Frank Zufall

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

WHOLE-cell patch clamp recordings detected a previously unidentified cGMP-activated membrane conductance in cultured rat hippocampal neurons. This conductance is nonselectively permeable for cations and is completely but reversibly blocked by external Cd²⁺. The Ca permeability of the hippocampal cGMP-activated conductance was examined in detail, indicating that the underlying ion channels display a high relative permeability for Ca²⁺. The results indicate that hippocampal neurons contain a cGMP-activated membrane conductance that has some properties similar to the cyclic nucleotide-gated channels previously shown in sensory receptor cells and retinal neurons. In hippocampal neurons this conductance similarly could mediate membrane depolarization and Ca²⁺ fluxes in response to intracellular cGMP elevation.

Original language	English (US)
Pages (from-to)	1761-1765
Number of pages	5
Journal	Neuroreport
Volume	6
Issue number	13
DOIs	https://doi.org/10.1097/00001756-199509000-00013
State	Published - Sep 1995

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General Neuroscience

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10.1097/00001756-199509000-00013

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abstract = "WHOLE-cell patch clamp recordings detected a previously unidentified cGMP-activated membrane conductance in cultured rat hippocampal neurons. This conductance is nonselectively permeable for cations and is completely but reversibly blocked by external Cd2+. The Ca permeability of the hippocampal cGMP-activated conductance was examined in detail, indicating that the underlying ion channels display a high relative permeability for Ca2+. The results indicate that hippocampal neurons contain a cGMP-activated membrane conductance that has some properties similar to the cyclic nucleotide-gated channels previously shown in sensory receptor cells and retinal neurons. In hippocampal neurons this conductance similarly could mediate membrane depolarization and Ca2+ fluxes in response to intracellular cGMP elevation.",

author = "Trese Leinders-Zufall and Hendrik Rosenboom and Barnstable, {Colin J.} and Shepherd, {Gordon M.} and Frank Zufall",

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AU - Leinders-Zufall, Trese

AU - Rosenboom, Hendrik

AU - Barnstable, Colin J.

AU - Shepherd, Gordon M.

AU - Zufall, Frank

PY - 1995/9

Y1 - 1995/9

N2 - WHOLE-cell patch clamp recordings detected a previously unidentified cGMP-activated membrane conductance in cultured rat hippocampal neurons. This conductance is nonselectively permeable for cations and is completely but reversibly blocked by external Cd2+. The Ca permeability of the hippocampal cGMP-activated conductance was examined in detail, indicating that the underlying ion channels display a high relative permeability for Ca2+. The results indicate that hippocampal neurons contain a cGMP-activated membrane conductance that has some properties similar to the cyclic nucleotide-gated channels previously shown in sensory receptor cells and retinal neurons. In hippocampal neurons this conductance similarly could mediate membrane depolarization and Ca2+ fluxes in response to intracellular cGMP elevation.

AB - WHOLE-cell patch clamp recordings detected a previously unidentified cGMP-activated membrane conductance in cultured rat hippocampal neurons. This conductance is nonselectively permeable for cations and is completely but reversibly blocked by external Cd2+. The Ca permeability of the hippocampal cGMP-activated conductance was examined in detail, indicating that the underlying ion channels display a high relative permeability for Ca2+. The results indicate that hippocampal neurons contain a cGMP-activated membrane conductance that has some properties similar to the cyclic nucleotide-gated channels previously shown in sensory receptor cells and retinal neurons. In hippocampal neurons this conductance similarly could mediate membrane depolarization and Ca2+ fluxes in response to intracellular cGMP elevation.

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A calcium-permeable cGMP-activated cation conductance in hippocampal neurons

Abstract

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