TY - JOUR
T1 - A case-control study of maternal exposure to chromium and infant low birth weight in China
AU - Xia, Wei
AU - Hu, Jie
AU - Zhang, Bin
AU - Li, Yuanyuan
AU - Wise, John Pierce
AU - Bassig, Bryan A.
AU - Zhou, Aifen
AU - Savitz, David A.
AU - Xiong, Chao
AU - Zhao, Jinzhu
AU - du, Xiaofu
AU - Zhou, Yanqiu
AU - Pan, Xinyun
AU - Yang, Jie
AU - Wu, Chuansha
AU - Jiang, Minmin
AU - Peng, Yang
AU - Qian, Zhengmin
AU - Zheng, Tongzhang
AU - Xu, Shunqing
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Exposure to chromium is increasing due to environmental pollution from industrial processes. Several epidemiological studies have investigated chromium exposure and reproductive outcomes, but few studies have investigated the association of chromium exposure and low birth weight (LBW). This study was designed to investigate whether maternal exposure to chromium during pregnancy is associated with an increased risk of LBW. Chromium concentrations in maternal urine samples collected at delivery were measured in 204 LBW cases and 612 matched controls recruited between 2012 and 2014 in Hubei Province, China. Risk of LBW was associated with higher levels of chromium in maternal urine [adjusted odds ratio (OR) = 1.77 for the medium tertile, 95% confidence interval (CI): 0.95, 3.29; adjusted OR = 2.48 for the highest tertile, 95% CI: 1.33, 4.61; P trend = 0.01]. The association was more pronounced among female infants (adjusted OR = 3.67 for the highest tertile, 95% CI: 1.50, 8.97) than among male infants (adjusted OR = 1.22 for the highest tertile, 95% CI = 0.48, 3.11) (p heterogeneity = 0.06). Our findings suggest that maternal exposure to higher levels of chromium during pregnancy may potentially increase the risk of delivering LBW infants, particularly for female infants.
AB - Exposure to chromium is increasing due to environmental pollution from industrial processes. Several epidemiological studies have investigated chromium exposure and reproductive outcomes, but few studies have investigated the association of chromium exposure and low birth weight (LBW). This study was designed to investigate whether maternal exposure to chromium during pregnancy is associated with an increased risk of LBW. Chromium concentrations in maternal urine samples collected at delivery were measured in 204 LBW cases and 612 matched controls recruited between 2012 and 2014 in Hubei Province, China. Risk of LBW was associated with higher levels of chromium in maternal urine [adjusted odds ratio (OR) = 1.77 for the medium tertile, 95% confidence interval (CI): 0.95, 3.29; adjusted OR = 2.48 for the highest tertile, 95% CI: 1.33, 4.61; P trend = 0.01]. The association was more pronounced among female infants (adjusted OR = 3.67 for the highest tertile, 95% CI: 1.50, 8.97) than among male infants (adjusted OR = 1.22 for the highest tertile, 95% CI = 0.48, 3.11) (p heterogeneity = 0.06). Our findings suggest that maternal exposure to higher levels of chromium during pregnancy may potentially increase the risk of delivering LBW infants, particularly for female infants.
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U2 - 10.1016/j.chemosphere.2015.10.006
DO - 10.1016/j.chemosphere.2015.10.006
M3 - Article
C2 - 26498095
AN - SCOPUS:84953775643
SN - 0045-6535
VL - 144
SP - 1484
EP - 1489
JO - Chemosphere
JF - Chemosphere
ER -