A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

Rahmad Akbar; Philippe A. Robert; Milena Pavlović; Jeliazko R. Jeliazkov; Igor Snapkov; Andrei Slabodkin; Cédric R. Weber; Lonneke Scheffer; Enkelejda Miho; Ingrid Hobæk Haff; Dag Trygve Tryslew Haug; Fridtjof Lund-Johansen; Yana Safonova; Geir K. Sandve; Victor Greiff

doi:10.1016/j.celrep.2021.108856

A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

Rahmad Akbar, Philippe A. Robert, Milena Pavlović, Jeliazko R. Jeliazkov, Igor Snapkov, Andrei Slabodkin, Cédric R. Weber, Lonneke Scheffer, Enkelejda Miho, Ingrid Hobæk Haff, Dag Trygve Tryslew Haug, Fridtjof Lund-Johansen, Yana Safonova, Geir K. Sandve, Victor Greiff

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106 Scopus citations

Abstract

Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.

Original language	English (US)
Article number	108856
Journal	Cell Reports
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2021.108856
State	Published - Mar 16 2021

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2021.108856

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Akbar, R., Robert, P. A., Pavlović, M., Jeliazkov, J. R., Snapkov, I., Slabodkin, A., Weber, C. R., Scheffer, L., Miho, E., Haff, I. H., Haug, D. T. T., Lund-Johansen, F., Safonova, Y., Sandve, G. K., & Greiff, V. (2021). A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding. Cell Reports, 34(11), Article 108856. https://doi.org/10.1016/j.celrep.2021.108856

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abstract = "Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.",

author = "Rahmad Akbar and Robert, {Philippe A.} and Milena Pavlovi{\'c} and Jeliazkov, {Jeliazko R.} and Igor Snapkov and Andrei Slabodkin and Weber, {C{\'e}dric R.} and Lonneke Scheffer and Enkelejda Miho and Haff, {Ingrid Hob{\ae}k} and Haug, {Dag Trygve Tryslew} and Fridtjof Lund-Johansen and Yana Safonova and Sandve, {Geir K.} and Victor Greiff",

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Akbar, R, Robert, PA, Pavlović, M, Jeliazkov, JR, Snapkov, I, Slabodkin, A, Weber, CR, Scheffer, L, Miho, E, Haff, IH, Haug, DTT, Lund-Johansen, F, Safonova, Y, Sandve, GK & Greiff, V 2021, 'A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding', Cell Reports, vol. 34, no. 11, 108856. https://doi.org/10.1016/j.celrep.2021.108856

TY - JOUR

T1 - A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

AU - Akbar, Rahmad

AU - Robert, Philippe A.

AU - Pavlović, Milena

AU - Jeliazkov, Jeliazko R.

AU - Snapkov, Igor

AU - Slabodkin, Andrei

AU - Weber, Cédric R.

AU - Scheffer, Lonneke

AU - Miho, Enkelejda

AU - Haff, Ingrid Hobæk

AU - Haug, Dag Trygve Tryslew

AU - Lund-Johansen, Fridtjof

AU - Safonova, Yana

AU - Sandve, Geir K.

AU - Greiff, Victor

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.

AB - Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.

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JO - Cell Reports

JF - Cell Reports

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A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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