A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

Rahmad Akbar; Philippe A. Robert; Milena Pavlović; Jeliazko R. Jeliazkov; Igor Snapkov; Andrei Slabodkin; Cédric R. Weber; Lonneke Scheffer; Enkelejda Miho; Ingrid Hobæk Haff; Dag Trygve Tryslew Haug; Fridtjof Lund-Johansen; Yana Safonova; Geir K. Sandve; Victor Greiff

doi:10.1016/j.celrep.2021.108856

A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

Rahmad Akbar
, Philippe A. Robert
, Milena Pavlović
, Jeliazko R. Jeliazkov
, Igor Snapkov
, Andrei Slabodkin
, Cédric R. Weber
, Lonneke Scheffer
, Enkelejda Miho
, Ingrid Hobæk Haff
, Dag Trygve Tryslew Haug
, Fridtjof Lund-Johansen
, Yana Safonova
, Geir K. Sandve
, Victor Greiff

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.

Original language	English (US)
Article number	108856
Journal	Cell Reports
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2021.108856
State	Published - Mar 16 2021

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2021.108856

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Akbar, R., Robert, P. A., Pavlović, M., Jeliazkov, J. R., Snapkov, I., Slabodkin, A., Weber, C. R., Scheffer, L., Miho, E., Haff, I. H., Haug, D. T. T., Lund-Johansen, F., Safonova, Y., Sandve, G. K., & Greiff, V. (2021). A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding. Cell Reports, 34(11), Article 108856. https://doi.org/10.1016/j.celrep.2021.108856

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abstract = "Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.",

author = "Rahmad Akbar and Robert, \{Philippe A.\} and Milena Pavlovi{\'c} and Jeliazkov, \{Jeliazko R.\} and Igor Snapkov and Andrei Slabodkin and Weber, \{C{\'e}dric R.\} and Lonneke Scheffer and Enkelejda Miho and Haff, \{Ingrid Hob{\ae}k\} and Haug, \{Dag Trygve Tryslew\} and Fridtjof Lund-Johansen and Yana Safonova and Sandve, \{Geir K.\} and Victor Greiff",

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Akbar, R, Robert, PA, Pavlović, M, Jeliazkov, JR, Snapkov, I, Slabodkin, A, Weber, CR, Scheffer, L, Miho, E, Haff, IH, Haug, DTT, Lund-Johansen, F, Safonova, Y, Sandve, GK & Greiff, V 2021, 'A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding', Cell Reports, vol. 34, no. 11, 108856. https://doi.org/10.1016/j.celrep.2021.108856

TY - JOUR

T1 - A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

AU - Akbar, Rahmad

AU - Robert, Philippe A.

AU - Pavlović, Milena

AU - Jeliazkov, Jeliazko R.

AU - Snapkov, Igor

AU - Slabodkin, Andrei

AU - Weber, Cédric R.

AU - Scheffer, Lonneke

AU - Miho, Enkelejda

AU - Haff, Ingrid Hobæk

AU - Haug, Dag Trygve Tryslew

AU - Lund-Johansen, Fridtjof

AU - Safonova, Yana

AU - Sandve, Geir K.

AU - Greiff, Victor

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.

AB - Prediction of antibody-antigen binding is a central question in immunology and of high relevance for predictive antibody and vaccine design. Akbar et al. prove the predictability of antibody-antigen binding by discovering a universal, compact, and immunity-specific motif vocabulary of paratope-epitope interactions.

UR - https://www.scopus.com/pages/publications/85102581207

UR - https://www.scopus.com/pages/publications/85102581207#tab=citedBy

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DO - 10.1016/j.celrep.2021.108856

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C2 - 33730590

AN - SCOPUS:85102581207

SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 11

M1 - 108856

ER -

A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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