Abstract
Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.
Original language | English (US) |
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Pages (from-to) | 206-211 |
Number of pages | 6 |
Journal | Biomarkers |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - May 2011 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis