A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

Joshua E. Muscat; Anderson Liu; John P. Richie

doi:10.3109/1354750X.2010.538084

A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

Joshua E. Muscat, Anderson Liu, John P. Richie

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33 Scopus citations

Abstract

Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

Original language	English (US)
Pages (from-to)	206-211
Number of pages	6
Journal	Biomarkers
Volume	16
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2010.538084
State	Published - May 2011

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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title = "A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine",

abstract = "Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.",

author = "Muscat, {Joshua E.} and Anderson Liu and Richie, {John P.}",

note = "Funding Information: The authors have no financial disclaimers. This work was supported by research grants PO1 CA68384 and K07 CA104231 from the National Cancer Institute.",

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doi = "10.3109/1354750X.2010.538084",

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T1 - A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

AU - Muscat, Joshua E.

AU - Liu, Anderson

AU - Richie, John P.

N1 - Funding Information: The authors have no financial disclaimers. This work was supported by research grants PO1 CA68384 and K07 CA104231 from the National Cancer Institute.

PY - 2011/5

Y1 - 2011/5

N2 - Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

AB - Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

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A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

Abstract

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