A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

Joshua E. Muscat; Anderson Liu; John P. Richie

doi:10.3109/1354750X.2010.538084

A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

Joshua E. Muscat, Anderson Liu, John P. Richie

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

Original language	English (US)
Pages (from-to)	206-211
Number of pages	6
Journal	Biomarkers
Volume	16
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2010.538084
State	Published - May 2011

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

Access to Document

10.3109/1354750X.2010.538084

Cite this

@article{8bf5aca2eb16448697a345ec2def0eef,

title = "A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine",

abstract = "Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.",

author = "Muscat, {Joshua E.} and Anderson Liu and Richie, {John P.}",

note = "Funding Information: The authors have no financial disclaimers. This work was supported by research grants PO1 CA68384 and K07 CA104231 from the National Cancer Institute.",

year = "2011",

month = may,

doi = "10.3109/1354750X.2010.538084",

language = "English (US)",

volume = "16",

pages = "206--211",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

AU - Muscat, Joshua E.

AU - Liu, Anderson

AU - Richie, John P.

N1 - Funding Information: The authors have no financial disclaimers. This work was supported by research grants PO1 CA68384 and K07 CA104231 from the National Cancer Institute.

PY - 2011/5

Y1 - 2011/5

N2 - Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

AB - Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

UR - http://www.scopus.com/inward/record.url?scp=79955106333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955106333&partnerID=8YFLogxK

U2 - 10.3109/1354750X.2010.538084

DO - 10.3109/1354750X.2010.538084

M3 - Article

C2 - 21288164

AN - SCOPUS:79955106333

SN - 1354-750X

VL - 16

SP - 206

EP - 211

JO - Biomarkers

JF - Biomarkers

IS - 3

ER -

A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this