A Comprehensive Review of COVID-19 Associated Neurological Manifestations

Chander Shekher Aggarwal, Sarah Walser, Abani Bhandari, Nikita Garg, Brendan McClafferty, Devyani Ramgobin, Reshma Golamari, Nitasa Sahu, Ashutosh Kumar, Rohit Jain

Research output: Contribution to journalReview articlepeer-review


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 utilizes the angiotensin-converting enzyme 2 (ACE-2) receptor of cells in order to gain entry and continue infection. Recent literature has focused on acute respiratory distress syndrome (ARDS) and other associated pulmonary complications; however, only a scarce amount of literature exists on neurological complications. Such complications also pose a high morbidity in these patients. The exact pathogenesis of nervous system involvement by COVID-19 still remains poorly understood. The aim of this article is to review the neurological symptoms seen in COVID-19 infection and discuss the probable pathogenesis, management and outcome of associated neurological complications.

Original languageEnglish (US)
Pages (from-to)569-571
Number of pages3
JournalSouth Dakota medicine : the journal of the South Dakota State Medical Association
Issue number12
StatePublished - Dec 1 2020

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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