A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

Ned D. Heindel; C. Jeffrey Lacey; Roger Egolf; Belle N. Mease; Keith J. Schray

doi:10.1002/jhet.5570230425

A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

Ned D. Heindel, C. Jeffrey Lacey, Roger Egolf, Belle N. Mease, Keith J. Schray

Penn State Lehigh Valley

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.

Original language	English (US)
Pages (from-to)	1087-1090
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	23
Issue number	4
DOIs	https://doi.org/10.1002/jhet.5570230425
State	Published - 1986

All Science Journal Classification (ASJC) codes

Organic Chemistry

Access to Document

10.1002/jhet.5570230425

Cite this

@article{0c203f4d05eb4fbab26c46f5785b551a,

title = "A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones",

abstract = "Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.",

author = "Heindel, {Ned D.} and Lacey, {C. Jeffrey} and Roger Egolf and Mease, {Belle N.} and Schray, {Keith J.}",

year = "1986",

doi = "10.1002/jhet.5570230425",

language = "English (US)",

volume = "23",

pages = "1087--1090",

journal = "Journal of Heterocyclic Chemistry",

issn = "0022-152X",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

AU - Heindel, Ned D.

AU - Lacey, C. Jeffrey

AU - Egolf, Roger

AU - Mease, Belle N.

AU - Schray, Keith J.

PY - 1986

Y1 - 1986

N2 - Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.

AB - Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.

UR - http://www.scopus.com/inward/record.url?scp=0022995695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022995695&partnerID=8YFLogxK

U2 - 10.1002/jhet.5570230425

DO - 10.1002/jhet.5570230425

M3 - Article

AN - SCOPUS:0022995695

SN - 0022-152X

VL - 23

SP - 1087

EP - 1090

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 4

ER -

A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this