A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

Ned D. Heindel; C. Jeffrey Lacey; Roger Egolf; Belle N. Mease; Keith J. Schray

doi:10.1002/jhet.5570230425

A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

Ned D. Heindel, C. Jeffrey Lacey, Roger Egolf, Belle N. Mease, Keith J. Schray

Penn State Lehigh Valley

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.

Original language	English (US)
Pages (from-to)	1087-1090
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	23
Issue number	4
DOIs	https://doi.org/10.1002/jhet.5570230425
State	Published - 1986

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1002/jhet.5570230425

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title = "A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones",

abstract = "Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.",

author = "Heindel, {Ned D.} and Lacey, {C. Jeffrey} and Roger Egolf and Mease, {Belle N.} and Schray, {Keith J.}",

year = "1986",

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T1 - A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

AU - Heindel, Ned D.

AU - Lacey, C. Jeffrey

AU - Egolf, Roger

AU - Mease, Belle N.

AU - Schray, Keith J.

PY - 1986

Y1 - 1986

N2 - Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.

AB - Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.

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U2 - 10.1002/jhet.5570230425

DO - 10.1002/jhet.5570230425

M3 - Article

AN - SCOPUS:0022995695

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JF - Journal of Heterocyclic Chemistry

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ER -

A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones

Abstract

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