A Convenient Synthesis of trans-3’-Hydroxycotinine, a Major Nicotine Metabolite Found in the Urine of Tobacco Users

Dhimant Desai; Shantu Amin

doi:10.1021/tx00013a008

A Convenient Synthesis of trans-3’-Hydroxycotinine, a Major Nicotine Metabolite Found in the Urine of Tobacco Users

Dhimant Desai, Shantu Amin

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

trans-3’-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3’-hydroxycotinine from cotinine in two steps by using NaN[(CH₃)₃Si]₂ and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis.

Original language	English (US)
Pages (from-to)	47-48
Number of pages	2
Journal	Chemical research in toxicology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1021/tx00013a008
State	Published - 1990

All Science Journal Classification (ASJC) codes

Toxicology

Access to Document

10.1021/tx00013a008

Cite this

@article{99a176586ac54fca9c9faeb4376d04ae,

title = "A Convenient Synthesis of trans-3{\textquoteright}-Hydroxycotinine, a Major Nicotine Metabolite Found in the Urine of Tobacco Users",

abstract = "trans-3{\textquoteright}-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3{\textquoteright}-hydroxycotinine from cotinine in two steps by using NaN[(CH3)3Si]2 and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis.",

author = "Dhimant Desai and Shantu Amin",

year = "1990",

doi = "10.1021/tx00013a008",

language = "English (US)",

volume = "3",

pages = "47--48",

journal = "Chemical research in toxicology",

issn = "0893-228X",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - A Convenient Synthesis of trans-3’-Hydroxycotinine, a Major Nicotine Metabolite Found in the Urine of Tobacco Users

AU - Desai, Dhimant

AU - Amin, Shantu

PY - 1990

Y1 - 1990

N2 - trans-3’-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3’-hydroxycotinine from cotinine in two steps by using NaN[(CH3)3Si]2 and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis.

AB - trans-3’-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3’-hydroxycotinine from cotinine in two steps by using NaN[(CH3)3Si]2 and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis.

UR - http://www.scopus.com/inward/record.url?scp=0025235960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025235960&partnerID=8YFLogxK

U2 - 10.1021/tx00013a008

DO - 10.1021/tx00013a008

M3 - Article

C2 - 2131824

AN - SCOPUS:0025235960

SN - 0893-228X

VL - 3

SP - 47

EP - 48

JO - Chemical research in toxicology

JF - Chemical research in toxicology

IS - 1

ER -

A Convenient Synthesis of trans-3’-Hydroxycotinine, a Major Nicotine Metabolite Found in the Urine of Tobacco Users

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this