TY - JOUR
T1 - A folding pathway-dependent score to recognize membrane proteins
AU - Hadi-Alijanvand, Hamid
AU - Rouhani, Maryam
AU - Proctor, Elizabeth A.
AU - Dokholyan, Nikolay V.
AU - Moosavi-Movahedi, Ali A.
N1 - Funding Information:
The support of the Research Council of the University of Tehran and Iran National Science Foundation (INSF) is gratefully acknowledged.
PY - 2011
Y1 - 2011
N2 - While various approaches exist to study protein localization, it is still a challenge to predict where proteins localize. Here, we consider a mechanistic viewpoint for membrane localization. Taking into account the steps for the folding pathway of α-helical membrane proteins and relating biophysical parameters to each of these steps, we create a score capable of predicting the propensity for membrane localization and call it FP3mem. This score is driven from the principal component analysis (PCA) of the biophysical parameters related to membrane localization. FP3mem allows us to rationalize the colocalization of a number of channel proteins with the Cav1.2 channel by their fewer propensities for membrane localization.
AB - While various approaches exist to study protein localization, it is still a challenge to predict where proteins localize. Here, we consider a mechanistic viewpoint for membrane localization. Taking into account the steps for the folding pathway of α-helical membrane proteins and relating biophysical parameters to each of these steps, we create a score capable of predicting the propensity for membrane localization and call it FP3mem. This score is driven from the principal component analysis (PCA) of the biophysical parameters related to membrane localization. FP3mem allows us to rationalize the colocalization of a number of channel proteins with the Cav1.2 channel by their fewer propensities for membrane localization.
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U2 - 10.1371/journal.pone.0016778
DO - 10.1371/journal.pone.0016778
M3 - Article
C2 - 21390303
AN - SCOPUS:79952292841
SN - 1932-6203
VL - 6
JO - PloS one
JF - PloS one
IS - 3
M1 - e16778
ER -