A Health Policy Model of CKD: 2. The Cost-Effectiveness of Microalbuminuria Screening

Thomas J. Hoerger, John S. Wittenborn, Joel E. Segel, Nilka R. Burrows, Kumiko Imai, Paul Eggers, Meda E. Pavkov, Regina Jordan, Susan M. Hailpern, Anton C. Schoolwerth, Desmond E. Williams

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Background: Microalbuminuria screening may detect chronic kidney disease in its early stages, allowing for treatment that delays or prevents disease progression. The cost-effectiveness of microalbuminuria screening has not been determined. Study Design: A cost-effectiveness model simulating disease progression and costs. Setting & Population: US patients. Model, Perspective, and Timeframe: The microsimulation model follows up disease progression and costs in a cohort of simulated patients from age 50 to 90 years or death. Costs are evaluated from the health care system perspective. Intervention: Microalbuminuria screening at 1-, 2-, 5-, or 10-year intervals followed by treatment with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. We considered universal screening, as well as screening targeted at persons with diabetes, persons with hypertension but no diabetes, and persons with neither diabetes nor hypertension. Outcomes: Costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios. Results: For the full model population, universal screening increases costs and increases QALYs. Universal annual screening starting at age 50 years has a cost-effectiveness ratio of $73,000/QALY relative to no screening and $145,000/QALY relative to usual care. Cost-effectiveness ratios improved with longer screening intervals. Relative to no screening, targeted annual screening has cost-effectiveness ratios of $21,000/QALY, $55,000/QALY, and $155,000/QALY for persons with diabetes, those with hypertension, and those with neither current diabetes nor current hypertension, respectively. Limitations: Results necessarily are based on a microsimulation model because of the long time horizon appropriate for chronic kidney disease. The model includes only health care costs. Conclusions: Microalbuminuria screening is cost-effective for patients with diabetes or hypertension, but is not cost-effective for patients with neither diabetes nor hypertension unless screening is conducted at longer intervals or as part of existing physician visits.

Original languageEnglish (US)
Pages (from-to)463-473
Number of pages11
JournalAmerican Journal of Kidney Diseases
Issue number3
StatePublished - Mar 2010

All Science Journal Classification (ASJC) codes

  • Nephrology


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