A high-fat meal increases cardiovascular reactivity to psychological stress in healthy young adults

Fabijana Jakulj, Kristin Zernicke, Simon L. Bacon, Laura E. Van Wielingen, Brenda L. Key, Sheila G. West, Tavis S. Campbell

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The consumption of high levels of saturated fat over the course of several weeks may lead to exaggerated cardiovascular reactivity. The consumption of a single high-fat meal has been associated with a transient impairment of vascular function. In a randomized, repeated measures, crossover study we tested whether the consumption of a single high-fat meal by healthy, normotensive participants would affect cardiovascular reactivity when compared with an isocaloric, low-fat meal. Thirty healthy participants ate a high-fat (42 g) and a low-fat (1 g) meal on 2 separate occasions, and their cardiovascular response to 2 standard laboratory stressors was measured. Systolic blood pressure, diastolic blood pressure, and total peripheral resistance were greater in participants following the consumption of the high-fat meal relative to the low-fat meal. The findings of the present study are consistent with the hypothesis that even a single high-fat meal may be associated with heightened cardiovascular reactivity to stress and offer insight into the pathways through which a high-fat diet may affect cardiovascular function.

Original languageEnglish (US)
Pages (from-to)935-939
Number of pages5
JournalJournal of Nutrition
Volume137
Issue number4
DOIs
StatePublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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