A Highly Sensitive and Long-Term Stable Wearable Patch for Continuous Analysis of Biomarkers in Sweat

Farnaz Lorestani, Xianzhe Zhang, Abu Musa Abdullah, Xin Xin, Yushen Liu, Md Mashfiqur Rahman, Md Abu Sayeed Biswas, Bowen Li, Ankan Dutta, Zhenyuan Niu, Shuvendu Das, Shishir Barai, Ke Wang, Huanyu Cheng

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5 Scopus citations

Abstract

Although increasing efforts have been devoted to the development of non-invasive wearable electrochemical sweat sensors for monitoring physiological and metabolic information, most of them still suffer from poor stability and specificity over time and fluctuating temperatures. This study reports the design and fabrication of a long-term stable and highly sensitive flexible electrochemical sensor based on nanocomposite-modified porous graphene by facile laser treatment for detecting biomarkers such as glucose in sweat. The laser-reduced and patterned stable conductive nanocomposite on the porous graphene electrode provides the resulting glucose sensor with an excellent sensitivity of 1317.69 µA mm−1 cm−2 and an ultra-low limit of detection of 0.079 µm. The sensor can also detect pH and exhibit extraordinary stability to maintain more than 91% sensitivity over 21 days in ambient conditions. Taken together with a temperature sensor based on the same material system, the dual glucose and pH sensor integrated with a flexible microfluidic sweat sampling network further results in accurate continuous on-body glucose detection calibrated by the simultaneously measured pH and temperature. The low-cost, highly sensitive, and long-term stable platform could facilitate the early identification and continuous monitoring of different biomarkers for non-invasive disease diagnosis and treatment evaluation.

Original languageEnglish (US)
Article number2306117
JournalAdvanced Functional Materials
Volume33
Issue number52
DOIs
StatePublished - Dec 22 2023

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Biomaterials
  • General Materials Science
  • Condensed Matter Physics
  • Electrochemistry

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