Abstract
This paper reports a hybrid electrokinetic processor that combines electrophoresis (EP), dielectrophoresis (DEP) and AC electrothermal flow (ACEF) for isolating exfoliated cancer cells (ECCs) and circulating tumor cells (CTCs) in physiological samples. While most electrokinetic techniques only function in low-conductivity buffers, hybrid electrokinetics enables effective operation in high-conductivity physiological fluids (∼ 1 S/m) such as blood, buffy coat and urine. Using a 3-electrode configuration with optimized AC voltage, frequency and DC offset, we demonstrate that breast cancer cells can be isolated in buffy coats and biological fluids in 10 sec.
| Original language | English (US) |
|---|---|
| Title of host publication | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
| Pages | 1472-1474 |
| Number of pages | 3 |
| State | Published - 2011 |
| Event | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States Duration: Oct 2 2011 → Oct 6 2011 |
Publication series
| Name | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
|---|---|
| Volume | 3 |
Other
| Other | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
|---|---|
| Country/Territory | United States |
| City | Seattle, WA |
| Period | 10/2/11 → 10/6/11 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
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