TY - GEN
T1 - A Mathematical Model of Nitric Oxide Mechanotransduction in Brain
AU - Tamis, Andrew
AU - Drapaca, Corina S.
N1 - Publisher Copyright:
© The Society for Experimental Mechanics, Inc. 2021.
PY - 2021
Y1 - 2021
N2 - Nitric Oxide (NO) is a diffusible molecule that is involved in many key signaling processes within the brain, notably the regulation of cerebral blood flow and pressure. NO is produced within neurons, endothelial cells, and red blood cells, but is only activated within the endothelial cells by the shear stress at the blood-endothelium interface. Because of the NO significance to brain functionality, various mathematical models of NO behavior have been proposed in literature. However, most of these models do not thoroughly incorporate the NO production in the endothelium through mechanotransduction. In a recent paper, we proposed a mathematical model to describe the steady-state behavior of NO in the brain that accounts for the shear-induced endothelial NO production and the Poiseuille-like flow of blood. In this paper we expand upon this model by introducing a deformable vascular wall and pulsatile blood flow. The arterial wall is modeled as a Maxwell linear viscoelastic material. Numerical simulations will show the mechanical effects on the spatio-temporal distribution of NO.
AB - Nitric Oxide (NO) is a diffusible molecule that is involved in many key signaling processes within the brain, notably the regulation of cerebral blood flow and pressure. NO is produced within neurons, endothelial cells, and red blood cells, but is only activated within the endothelial cells by the shear stress at the blood-endothelium interface. Because of the NO significance to brain functionality, various mathematical models of NO behavior have been proposed in literature. However, most of these models do not thoroughly incorporate the NO production in the endothelium through mechanotransduction. In a recent paper, we proposed a mathematical model to describe the steady-state behavior of NO in the brain that accounts for the shear-induced endothelial NO production and the Poiseuille-like flow of blood. In this paper we expand upon this model by introducing a deformable vascular wall and pulsatile blood flow. The arterial wall is modeled as a Maxwell linear viscoelastic material. Numerical simulations will show the mechanical effects on the spatio-temporal distribution of NO.
UR - https://www.scopus.com/pages/publications/85142840228
UR - https://www.scopus.com/pages/publications/85142840228#tab=citedBy
U2 - 10.1007/978-3-030-59765-8_6
DO - 10.1007/978-3-030-59765-8_6
M3 - Conference contribution
AN - SCOPUS:85142840228
SN - 9783030597641
T3 - Conference Proceedings of the Society for Experimental Mechanics Series
SP - 29
EP - 34
BT - Mechanics of Biological Systems and Materials and Micro-and Nanomechanics and Research Applications - Proceedings of the 2020 Annual Conference on Experimental and Applied Mechanics
A2 - Notbohm, Jacob
A2 - Franck, Christian
A2 - Karanjgaokar, Nikhil
A2 - DelRio, Frank W.
PB - Springer
T2 - SEM Annual Conference and Exposition on Experimental and Applied Mechanics, 2020
Y2 - 14 September 2020 through 17 September 2020
ER -