TY - GEN
T1 - A mechanoregulation approach for probing substrate elasticities and geometric constraints on differentiation of human neuroblastoma
AU - Nam, K. H.
AU - Mfoumou, E.
AU - Wong, P. K.
PY - 2011
Y1 - 2011
N2 - Cellular differentiations are regulated by various mechanical and physical factors in their local microenvironment, such as cell-substrate interactions and geometric confinements. Understanding the systematic mechanisms of these factors in cell mechanoregulation is critical for fundamental cell biology and development of novel approaches in tissue engineering and regenerative medicine. Here, we investigate the differentiation of human neuroblastoma cells on various substrates with different elastic moduli controlled by the crosslinker concentration of PDMS and with different geometric constraints created by plasma lithographic surface modification. This mechanoregulation approach allows systematic investigation of the effects of the interrelated mechanical factors, i.e., geometric confinement and substrate elasticity, on cellular differentiation and other biological processes.
AB - Cellular differentiations are regulated by various mechanical and physical factors in their local microenvironment, such as cell-substrate interactions and geometric confinements. Understanding the systematic mechanisms of these factors in cell mechanoregulation is critical for fundamental cell biology and development of novel approaches in tissue engineering and regenerative medicine. Here, we investigate the differentiation of human neuroblastoma cells on various substrates with different elastic moduli controlled by the crosslinker concentration of PDMS and with different geometric constraints created by plasma lithographic surface modification. This mechanoregulation approach allows systematic investigation of the effects of the interrelated mechanical factors, i.e., geometric confinement and substrate elasticity, on cellular differentiation and other biological processes.
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M3 - Conference contribution
AN - SCOPUS:84883814713
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 1008
EP - 1010
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -
