A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs)

D. G. Patterson; W. E. Turner; S. G. Isaacs; L. R. Alexander

doi:10.1016/0045-6535(90)90189-Z

A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs)

D. G. Patterson, W. E. Turner, S. G. Isaacs, L. R. Alexander

Forensic Science Program

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Over the past 5 years, the Centers for Disease Control had analyzed more than 5,000 adipose tissue and serum samples for PCDDs and PCDFs. These samples have been collected under strict protocols for large-scale studies including: 1) The Agent Orange Vietnam Veteran Validation Study; 2) The Missouri Adipose Tissue Study; 3) The Air Force Ranch Hand Study; 4) The NIOSH Worker Study; as well as several smaller studies. Because of our extensive quality assurance program over the years, we have been able to identify several major areas of potential analytical contamination that should be avoided by laboratories performing analyses of biological samples. We also present the results of long-term stability studies of 2378-TCDD in adipose tissue and serum (5-6 years) as well as the stability of PCDDs and PCDFs after they have been extracted from the sample matrix. In addition, we discuss the results of a performance evaluation of our method which includes small interlaboratory studies with other laboratories performing PCDD and PCDF analyses in biological samples.

Original language	English (US)
Pages (from-to)	829-836
Number of pages	8
Journal	Chemosphere
Volume	20
Issue number	7-9
DOIs	https://doi.org/10.1016/0045-6535(90)90189-Z
State	Published - 1990

All Science Journal Classification (ASJC) codes

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Health, Toxicology and Mutagenesis

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title = "A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs)",

abstract = "Over the past 5 years, the Centers for Disease Control had analyzed more than 5,000 adipose tissue and serum samples for PCDDs and PCDFs. These samples have been collected under strict protocols for large-scale studies including: 1) The Agent Orange Vietnam Veteran Validation Study; 2) The Missouri Adipose Tissue Study; 3) The Air Force Ranch Hand Study; 4) The NIOSH Worker Study; as well as several smaller studies. Because of our extensive quality assurance program over the years, we have been able to identify several major areas of potential analytical contamination that should be avoided by laboratories performing analyses of biological samples. We also present the results of long-term stability studies of 2378-TCDD in adipose tissue and serum (5-6 years) as well as the stability of PCDDs and PCDFs after they have been extracted from the sample matrix. In addition, we discuss the results of a performance evaluation of our method which includes small interlaboratory studies with other laboratories performing PCDD and PCDF analyses in biological samples.",

author = "Patterson, {D. G.} and Turner, {W. E.} and Isaacs, {S. G.} and Alexander, {L. R.}",

year = "1990",

doi = "10.1016/0045-6535(90)90189-Z",

language = "English (US)",

volume = "20",

pages = "829--836",

journal = "Chemosphere",

issn = "0045-6535",

publisher = "Elsevier Ltd",

number = "7-9",

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A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). / Patterson, D. G.; Turner, W. E.; Isaacs, S. G. et al.
In: Chemosphere, Vol. 20, No. 7-9, 1990, p. 829-836.

Research output: Contribution to journal › Article › peer-review

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AU - Alexander, L. R.

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AB - Over the past 5 years, the Centers for Disease Control had analyzed more than 5,000 adipose tissue and serum samples for PCDDs and PCDFs. These samples have been collected under strict protocols for large-scale studies including: 1) The Agent Orange Vietnam Veteran Validation Study; 2) The Missouri Adipose Tissue Study; 3) The Air Force Ranch Hand Study; 4) The NIOSH Worker Study; as well as several smaller studies. Because of our extensive quality assurance program over the years, we have been able to identify several major areas of potential analytical contamination that should be avoided by laboratories performing analyses of biological samples. We also present the results of long-term stability studies of 2378-TCDD in adipose tissue and serum (5-6 years) as well as the stability of PCDDs and PCDFs after they have been extracted from the sample matrix. In addition, we discuss the results of a performance evaluation of our method which includes small interlaboratory studies with other laboratories performing PCDD and PCDF analyses in biological samples.

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A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs)

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