TY - JOUR
T1 - A methodological checklist for fMRI drug cue reactivity studies
T2 - development and expert consensus
AU - Ekhtiari, Hamed
AU - Zare-Bidoky, Mehran
AU - Sangchooli, Arshiya
AU - Janes, Amy C.
AU - Kaufman, Marc J.
AU - Oliver, Jason A.
AU - Prisciandaro, James J.
AU - Wüstenberg, Torsten
AU - Anton, Raymond F.
AU - Bach, Patrick
AU - Baldacchino, Alex
AU - Beck, Anne
AU - Bjork, James M.
AU - Brewer, Judson
AU - Childress, Anna Rose
AU - Claus, Eric D.
AU - Courtney, Kelly E.
AU - Ebrahimi, Mohsen
AU - Filbey, Francesca M.
AU - Ghahremani, Dara G.
AU - Azbari, Peyman Ghobadi
AU - Goldstein, Rita Z.
AU - Goudriaan, Anna E.
AU - Grodin, Erica N.
AU - Hamilton, J. Paul
AU - Hanlon, Colleen A.
AU - Hassani-Abharian, Peyman
AU - Heinz, Andreas
AU - Joseph, Jane E.
AU - Kiefer, Falk
AU - Zonoozi, Arash Khojasteh
AU - Kober, Hedy
AU - Kuplicki, Rayus
AU - Li, Qiang
AU - London, Edythe D.
AU - McClernon, Joseph
AU - Noori, Hamid R.
AU - Owens, Max M.
AU - Paulus, Martin P.
AU - Perini, Irene
AU - Potenza, Marc
AU - Potvin, Stéphane
AU - Ray, Lara
AU - Schacht, Joseph P.
AU - Seo, Dongju
AU - Sinha, Rajita
AU - Smolka, Michael N.
AU - Spanagel, Rainer
AU - Steele, Vaughn R.
AU - Stein, Elliot A.
AU - Steins-Loeber, Sabine
AU - Tapert, Susan F.
AU - Verdejo-Garcia, Antonio
AU - Vollstädt-Klein, Sabine
AU - Wetherill, Reagan R.
AU - Wilson, Stephen J.
AU - Witkiewitz, Katie
AU - Yuan, Kai
AU - Zhang, Xiaochu
AU - Zilverstand, Anna
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/3
Y1 - 2022/3
N2 - Cue reactivity is one of the most frequently used paradigms in functional magnetic resonance imaging (fMRI) studies of substance use disorders (SUDs). Although there have been promising results elucidating the neurocognitive mechanisms of SUDs and SUD treatments, the interpretability and reproducibility of these studies is limited by incomplete reporting of participants’ characteristics, task design, craving assessment, scanning preparation and analysis decisions in fMRI drug cue reactivity (FDCR) experiments. This hampers clinical translation, not least because systematic review and meta-analysis of published work are difficult. This consensus paper and Delphi study aims to outline the important methodological aspects of FDCR research, present structured recommendations for more comprehensive methods reporting and review the FDCR literature to assess the reporting of items that are deemed important. Forty-five FDCR scientists from around the world participated in this study. First, an initial checklist of items deemed important in FDCR studies was developed by several members of the Enhanced NeuroImaging Genetics through Meta-Analyses (ENIGMA) Addiction working group on the basis of a systematic review. Using a modified Delphi consensus method, all experts were asked to comment on, revise or add items to the initial checklist, and then to rate the importance of each item in subsequent rounds. The reporting status of the items in the final checklist was investigated in 108 recently published FDCR studies identified through a systematic review. By the final round, 38 items reached the consensus threshold and were classified under seven major categories: ‘Participants’ Characteristics’, ‘General fMRI Information’, ‘General Task Information’, ‘Cue Information’, ‘Craving Assessment Inside Scanner’, ‘Craving Assessment Outside Scanner’ and ‘Pre- and Post-Scanning Considerations’. The review of the 108 FDCR papers revealed significant gaps in the reporting of the items considered important by the experts. For instance, whereas items in the ‘General fMRI Information’ category were reported in 90.5% of the reviewed papers, items in the ‘Pre- and Post-Scanning Considerations’ category were reported by only 44.7% of reviewed FDCR studies. Considering the notable and sometimes unexpected gaps in the reporting of items deemed to be important by experts in any FDCR study, the protocols could benefit from the adoption of reporting standards. This checklist, a living document to be updated as the field and its methods advance, can help improve experimental design, reporting and the widespread understanding of the FDCR protocols. This checklist can also provide a sample for developing consensus statements for protocols in other areas of task-based fMRI.
AB - Cue reactivity is one of the most frequently used paradigms in functional magnetic resonance imaging (fMRI) studies of substance use disorders (SUDs). Although there have been promising results elucidating the neurocognitive mechanisms of SUDs and SUD treatments, the interpretability and reproducibility of these studies is limited by incomplete reporting of participants’ characteristics, task design, craving assessment, scanning preparation and analysis decisions in fMRI drug cue reactivity (FDCR) experiments. This hampers clinical translation, not least because systematic review and meta-analysis of published work are difficult. This consensus paper and Delphi study aims to outline the important methodological aspects of FDCR research, present structured recommendations for more comprehensive methods reporting and review the FDCR literature to assess the reporting of items that are deemed important. Forty-five FDCR scientists from around the world participated in this study. First, an initial checklist of items deemed important in FDCR studies was developed by several members of the Enhanced NeuroImaging Genetics through Meta-Analyses (ENIGMA) Addiction working group on the basis of a systematic review. Using a modified Delphi consensus method, all experts were asked to comment on, revise or add items to the initial checklist, and then to rate the importance of each item in subsequent rounds. The reporting status of the items in the final checklist was investigated in 108 recently published FDCR studies identified through a systematic review. By the final round, 38 items reached the consensus threshold and were classified under seven major categories: ‘Participants’ Characteristics’, ‘General fMRI Information’, ‘General Task Information’, ‘Cue Information’, ‘Craving Assessment Inside Scanner’, ‘Craving Assessment Outside Scanner’ and ‘Pre- and Post-Scanning Considerations’. The review of the 108 FDCR papers revealed significant gaps in the reporting of the items considered important by the experts. For instance, whereas items in the ‘General fMRI Information’ category were reported in 90.5% of the reviewed papers, items in the ‘Pre- and Post-Scanning Considerations’ category were reported by only 44.7% of reviewed FDCR studies. Considering the notable and sometimes unexpected gaps in the reporting of items deemed to be important by experts in any FDCR study, the protocols could benefit from the adoption of reporting standards. This checklist, a living document to be updated as the field and its methods advance, can help improve experimental design, reporting and the widespread understanding of the FDCR protocols. This checklist can also provide a sample for developing consensus statements for protocols in other areas of task-based fMRI.
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U2 - 10.1038/s41596-021-00649-4
DO - 10.1038/s41596-021-00649-4
M3 - Review article
C2 - 35121856
AN - SCOPUS:85124372512
SN - 1754-2189
VL - 17
SP - 567
EP - 595
JO - Nature Protocols
JF - Nature Protocols
IS - 3
ER -