TY - GEN
T1 - A microfluidic-based platform for in vitro studies of cell signaling in blood vessels
AU - Riahi, R.
AU - Yang, Y.
AU - Kim, H.
AU - Jiang, L.
AU - Wong, P. K.
AU - Zohar, Y.
PY - 2013
Y1 - 2013
N2 - A microfluidic-based platform is developed for in vitro investigation of signaling within the blood-stream leading to preferential homing of specific cells such as white blood cells (WBCs) selectively to injured host organs. A microchannel has been coated with a monolayer of endothelial cells to mimic the microenvironment in blood vessels, while stable chemokine gradients have been generated locally at selected locations along the microchannel sidewalls. We demonstrate that both the chemokine gradients and the endothelial cells are simultaneously maintained during steady flow of cells as in the blood stream.
AB - A microfluidic-based platform is developed for in vitro investigation of signaling within the blood-stream leading to preferential homing of specific cells such as white blood cells (WBCs) selectively to injured host organs. A microchannel has been coated with a monolayer of endothelial cells to mimic the microenvironment in blood vessels, while stable chemokine gradients have been generated locally at selected locations along the microchannel sidewalls. We demonstrate that both the chemokine gradients and the endothelial cells are simultaneously maintained during steady flow of cells as in the blood stream.
UR - http://www.scopus.com/inward/record.url?scp=84891697108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891697108&partnerID=8YFLogxK
U2 - 10.1109/Transducers.2013.6626760
DO - 10.1109/Transducers.2013.6626760
M3 - Conference contribution
AN - SCOPUS:84891697108
SN - 9781467359818
T3 - 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
SP - 293
EP - 296
BT - 2013 Transducers and Eurosensors XXVII
T2 - 2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Y2 - 16 June 2013 through 20 June 2013
ER -