TY - JOUR
T1 - A model of the effects of applied electric fields on neuronal synchronization
AU - Park, Eun Hyoung
AU - Barreto, Ernest
AU - Gluckman, Bruce
AU - Schiff, Steven
AU - So, Paul
N1 - Funding Information:
We are grateful to R. Traub for helpful discussions. This work was supported by NIH grants K02MH01493 (SJS), K25MH01963 (EB), and R01MH50006 (SJS, PS, BJG).
PY - 2005/8
Y1 - 2005/8
N2 - We examine the effects of applied electric fields on neuronal synchronization. Two-compartment model neurons were synaptically coupled and embedded within a resistive array, thus allowing the neurons to interact both chemically and electrically. In addition, an external electric field was imposed on the array. The effects of this field were found to be nontrivial, giving rise to domains of synchrony and asynchrony as a function of the heterogeneity among the neurons. A simple phase oscillator reduction was successful in qualitatively reproducing these domains. The findings form several readily testable experimental predictions, and the model can be extended to a larger scale in which the effects of electric fields on seizure activity may be simulated.
AB - We examine the effects of applied electric fields on neuronal synchronization. Two-compartment model neurons were synaptically coupled and embedded within a resistive array, thus allowing the neurons to interact both chemically and electrically. In addition, an external electric field was imposed on the array. The effects of this field were found to be nontrivial, giving rise to domains of synchrony and asynchrony as a function of the heterogeneity among the neurons. A simple phase oscillator reduction was successful in qualitatively reproducing these domains. The findings form several readily testable experimental predictions, and the model can be extended to a larger scale in which the effects of electric fields on seizure activity may be simulated.
UR - https://www.scopus.com/pages/publications/24344483542
UR - https://www.scopus.com/inward/citedby.url?scp=24344483542&partnerID=8YFLogxK
U2 - 10.1007/s10827-005-0214-5
DO - 10.1007/s10827-005-0214-5
M3 - Article
C2 - 16133825
AN - SCOPUS:24344483542
SN - 0929-5313
VL - 19
SP - 53
EP - 70
JO - Journal of Computational Neuroscience
JF - Journal of Computational Neuroscience
IS - 1
ER -