A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge: A spectroscopic and theoretical investigation

Özlen F. Erdem; Lennart Schwartz; Matthias Stein; Alexey Silakov; Sandeep Kaur-Ghumaan; Ping Huang; Sascha Ott; Edward J. Reijerse; Wolfgang Lubitz

doi:10.1002/anie.201006244

A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge: A spectroscopic and theoretical investigation

Özlen F. Erdem
, Lennart Schwartz
, Matthias Stein
, Alexey Silakov
, Sandeep Kaur-Ghumaan
, Ping Huang
, Sascha Ott
, Edward J. Reijerse
, Wolfgang Lubitz

Chemistry

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Convincing evidence for the presence of a nitrogen atom in the dithiolate bridge of the active site of native [FeFe] hydrogenases (B) is provided by a spectroscopic, electrochemical, and theoretical study of a well-characterized structural mimic of the [FeFe] hydrogenase subcluster (picture: ¹⁴N matched-HYSCORE spectrum of the model compound A). This result should help to understand the mechanism of dihydrogen conversion and production.

Original language	English (US)
Pages (from-to)	1439-1443
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	6
DOIs	https://doi.org/10.1002/anie.201006244
State	Published - Feb 7 2011

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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10.1002/anie.201006244

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Erdem, Ö. F., Schwartz, L., Stein, M., Silakov, A., Kaur-Ghumaan, S., Huang, P., Ott, S., Reijerse, E. J., & Lubitz, W. (2011). A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge: A spectroscopic and theoretical investigation. Angewandte Chemie - International Edition, 50(6), 1439-1443. https://doi.org/10.1002/anie.201006244

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Erdem, ÖF, Schwartz, L, Stein, M, Silakov, A, Kaur-Ghumaan, S, Huang, P, Ott, S, Reijerse, EJ & Lubitz, W 2011, 'A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge: A spectroscopic and theoretical investigation', Angewandte Chemie - International Edition, vol. 50, no. 6, pp. 1439-1443. https://doi.org/10.1002/anie.201006244

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T2 - A spectroscopic and theoretical investigation

AU - Erdem, Özlen F.

AU - Schwartz, Lennart

AU - Stein, Matthias

AU - Silakov, Alexey

AU - Kaur-Ghumaan, Sandeep

AU - Huang, Ping

AU - Ott, Sascha

AU - Reijerse, Edward J.

AU - Lubitz, Wolfgang

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AB - Convincing evidence for the presence of a nitrogen atom in the dithiolate bridge of the active site of native [FeFe] hydrogenases (B) is provided by a spectroscopic, electrochemical, and theoretical study of a well-characterized structural mimic of the [FeFe] hydrogenase subcluster (picture: 14N matched-HYSCORE spectrum of the model compound A). This result should help to understand the mechanism of dihydrogen conversion and production.

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A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge: A spectroscopic and theoretical investigation

Abstract

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